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STUDIES ON THE EFFECT OF CERTAIN TOXIC SUBSTANCES IN BACTERIAL CULTURES ON THE MOVEMENT OF THE INTESTINES : I. THE EFFECT OF SOLUBLE TOXIC SUBSTANCES OF YOUNG CULTURES OF BACILLUS PARATYPHOSUS B.
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MedLine Citation:
PMID:  19869160     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Following intravenous injection, filtrates of young cultures of B. paratyphosus B often produce marked diarrhea in rabbits. A study was made of the effect of these toxic filtrates on the motility of the small intestines of the rabbit. The observations were made on a segment of the small intestines in situ, and in the living animal. It was found that an immediate slight rise of tone of the longitudinal muscles occurred following intravenous injection of sterile broth. The same rise was noted after the injection of the toxic filtrate; but with these it was followed later (10 minutes elapsing at least) by a very strong but gradual rise of the diastolic and systolic tone, i.e., by spasmodic contraction of the intestinal muscle, which persisted at times for as long as 2 hours. In order to record simultaneously the effect on the longitudinal and circular muscles, and the propulsive efficiency of the segment the Sollmann and Rademaekers modification of Baur's technique was employed. This arrangement showed that the stimulation of the longitudinal muscles is accompanied by a similarly strong stimulation of the circular muscles, by peristalsis, and therefore by a greatly increased propulsion of intestinal contents which was sufficient to overcome the inhibition that usually occurs after preparation of the animal. With this arrangement an instance of peristaltic spasm was also noted. Broth alone failed to produce the phenomenon. Isotonic magnesium chloride or sulfate added to the bath relaxed the muscles again. Animals under deep urethane anesthesia did not show the diarrhea occurring in the intact controls, but sometimes exhibited it after the effect of the anesthetic had disappeared. So far no effects have been observed on the isolated strip (Magnus method), and further studies are being made to localize the effect, to neutralize it with a specific antiserum, and to observe the effect of filtrates of other members of the bacterial group including the dysentery bacilli.
Authors:
E E Ecker; A Rademaekers
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of experimental medicine     Volume:  43     ISSN:  0022-1007     ISO Abbreviation:  J. Exp. Med.     Publication Date:  1926 May 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-06-23     Revised Date:  2010-09-28    
Medline Journal Info:
Nlm Unique ID:  2985109R     Medline TA:  J Exp Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  785-95     Citation Subset:  -    
Affiliation:
Departments of Pathology and Pharmacology of the School of Medicine of Western Reserve University, Cleveland.
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Full Text
Journal Information
Journal ID (nlm-ta): J Exp Med
ISSN: 0022-1007
ISSN: 1540-9538
Publisher: The Rockefeller University Press
Article Information
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Copyright © Copyright, 1926, by The Rockefeller Institute for Medical Research New York
Received Day: 3 Month: 3 Year: 1926
Print publication date: Day: 31 Month: 5 Year: 1926
Volume: 43 Issue: 6
First Page: 785 Last Page: 795
ID: 2131139
PubMed Id: 19869160

STUDIES ON THE EFFECT OF CERTAIN TOXIC SUBSTANCES IN BACTERIAL CULTURES ON THE MOVEMENT OF THE INTESTINES : I. THE EFFECT OF SOLUBLE TOXIC SUBSTANCES OF YOUNG CULTURES OF BACILLUS PARATYPHOSUS B.
E. E. Ecker
A. Rademaekers
From the Departments of Pathology and Pharmacology of the School of Medicine of Western Reserve University, Cleveland.


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