Document Detail

Studies on the dopamine-dependent modulation of amino acid-gated currents in cone horizontal cells of the perch (Perca fluviatilis).
MedLine Citation:
PMID:  8266644     Owner:  NLM     Status:  MEDLINE    
The whole-cell patch-clamp technique was employed to record membrane currents from isolated horizontal cells in culture. Concentration-response relationships for currents induced by L-glutamate, kainate and quisqualate were measured. Preincubation with dopamine changed the parameters of the concentration-response curves in a particular way for each agonist. The maximum currents induced by glutamate increased by 50-100% and the EC50-values were slightly shifted to higher values. The increase of kainate-induced maximum currents after dopamine incubation did not exceed 30% but the EC50-values were clearly shifted to lower concentrations. Quisqualate-induced maximum currents were not enhanced by dopamine preincubation but the EC50-values were shifted to lower concentrations. The dopamine-dependent modulation was affected by removal of magnesium and preincubation with concanavalin A and aniracetam. The concentration-response relation and the time-course of the dopamine effect on glutamate-induced currents is described.
M Kruse; K F Schmidt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Vision research     Volume:  33     ISSN:  0042-6989     ISO Abbreviation:  Vision Res.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-25     Completed Date:  1994-01-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417402     Medline TA:  Vision Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2031-42     Citation Subset:  IM    
Physiologisches Institut, Justus-Liebig-Universität Giessen, Germany.
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MeSH Terms
Concanavalin A / pharmacology
Dopamine / pharmacology*
Dose-Response Relationship, Drug
Glutamates / pharmacology
Kainic Acid / pharmacology
Membrane Potentials / drug effects
Perches / physiology*
Receptors, Glutamate / drug effects
Retinal Rod Photoreceptor Cells / physiology*
Reg. No./Substance:
0/Glutamates; 0/Receptors, Glutamate; 11028-71-0/Concanavalin A; 487-79-6/Kainic Acid

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