Document Detail


Studies on differential sensing of dopamine at the surface of chemically sensitized ormosil-modified electrodes.
MedLine Citation:
PMID:  18970271     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We report herein the preparation of few chemically sensitized organically modified sol-gel glass (ormosil) films and sensing of dopamine at the surface of the modified electrodes derived from these films. The chemical sensitization in ormosil-modified electrodes is introduced by incorporating: (a) potassium ferricyanide and (b) either Nafion, or dibenzo-18-crown-6 or in situ generated Prussian blue from potassium ferricyanide. Electrochemical sensing of dopamine on the surfaces of these modified electrodes have been investigated and found that: (i) the presence of dibenzo-18-crown-6 facilitate the magnitude of dopamine sensing, (ii) conversion of potassium ferricyanide into Prussian blue also enhances the magnitude of dopamine sensing as compared to that of control and Nafion sensitized modified electrodes, (iii) both dibenzo-18-crown-6 and Nafion sensitized ormosil-modified electrodes are found selective to dopamine in the presence of ascorbic acid present under physiological concentration range. These finding again directed our attention to investigate the sensing of dopamine: (a) on dibenzo-18-crown-6 incorporated within Prussian blue sensitized modified electrode and (b) in the presence of varying concentrations of dibenzo-18-crown-6 in the Prussian blue modified electrodes. The investigations made on these lines again suggested the following: (1) increase in dibenzo-18-crown-6 concentrations in the modified electrode increases the magnitude of dopamine sensing upto an optimum concentration of macrocycle; (2) the detection limit of dopamine sensing goes down to 30nM as compared to that of dibenzo-18-crown-6 incorporated with potassium ferricyanide which was found to the order of 100nM. Investigations of the interference of ascorbic acid revealed that the presence of dibenzo-18-crown-6 introduces selectivity in dopamine sensing in the presence such common interfering analyte like ascorbic acid.
Authors:
P C Pandey; B C Upadhyay
Publication Detail:
Type:  Journal Article     Date:  2005-05-31
Journal Detail:
Title:  Talanta     Volume:  67     ISSN:  1873-3573     ISO Abbreviation:  Talanta     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2008-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984816R     Medline TA:  Talanta     Country:  England    
Other Details:
Languages:  eng     Pagination:  997-1006     Citation Subset:  -    
Affiliation:
Department of Applied Chemistry, Institute of Technology, Banaras Hindu University, Varanasi 221 005, India.
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