| Studies on development of insoluble drugs as pharmaceutical suspensions by response surface methodology. | |
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MedLine Citation:
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PMID: 18972834 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The preformulation of insoluble drugs, trimethoprim and nitrofurantoin, was studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called "caking", and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful to determine optimal properties is a Box-Behnken design. The surfactant, thickener and electrolyte at different proportions were the three factors studied. This strategy allows to point on the main significant effect and to determine the concentrations of each product leading to optimal properties of the suspensions. |
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Authors:
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I S Khattab |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 63 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-31 Completed Date: 2008-12-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: Germany |
Other Details:
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Languages: eng Pagination: 726-30 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Kuwait. Khattab@hsc.edu.kw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carboxymethylcellulose Cellulose Chemistry, Pharmaceutical / statistics & numerical data* Data Interpretation, Statistical Drug Delivery Systems / statistics & numerical data* Excipients Folic Acid Antagonists / administration & dosage, chemistry Models, Statistical* Nitrofurantoin / administration & dosage, chemistry Polysorbates Solubility Surface-Active Agents Suspensions Trimethoprim / administration & dosage, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Excipients; 0/Folic Acid Antagonists; 0/Polysorbates; 0/Surface-Active Agents; 0/Suspensions; 0/microcrystalline cellulose; 67-20-9/Nitrofurantoin; 738-70-5/Trimethoprim; 9004-32-4/Carboxymethylcellulose; 9004-34-6/Cellulose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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