Document Detail


Studies on development of insoluble drugs as pharmaceutical suspensions by response surface methodology.
MedLine Citation:
PMID:  18972834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The preformulation of insoluble drugs, trimethoprim and nitrofurantoin, was studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called "caking", and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful to determine optimal properties is a Box-Behnken design. The surfactant, thickener and electrolyte at different proportions were the three factors studied. This strategy allows to point on the main significant effect and to determine the concentrations of each product leading to optimal properties of the suspensions.
Authors:
I S Khattab
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  63     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-31     Completed Date:  2008-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  726-30     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmacy, Health Science Center, Kuwait University, Kuwait. Khattab@hsc.edu.kw
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MeSH Terms
Descriptor/Qualifier:
Carboxymethylcellulose
Cellulose
Chemistry, Pharmaceutical / statistics & numerical data*
Data Interpretation, Statistical
Drug Delivery Systems / statistics & numerical data*
Excipients
Folic Acid Antagonists / administration & dosage,  chemistry
Models, Statistical*
Nitrofurantoin / administration & dosage,  chemistry
Polysorbates
Solubility
Surface-Active Agents
Suspensions
Trimethoprim / administration & dosage,  chemistry
Chemical
Reg. No./Substance:
0/Excipients; 0/Folic Acid Antagonists; 0/Polysorbates; 0/Surface-Active Agents; 0/Suspensions; 0/microcrystalline cellulose; 67-20-9/Nitrofurantoin; 738-70-5/Trimethoprim; 9004-32-4/Carboxymethylcellulose; 9004-34-6/Cellulose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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