Document Detail

Studies on the derivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid. I. Syntheses and pharmacological analysis of acylderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid.
MedLine Citation:
PMID:  398686     Owner:  NLM     Status:  MEDLINE    
A number of new acyl and imidoderivatives of 2-amino-4-p-chlorophenylthiazole-5-acetic acid (II) and its methyl ester (VII) were synthesized. Methyl ester VII heated in benzene solution with acid anhydrides was transformed into adequate acyl derivatives (VIII, IX, X, XIII, XVI). Some of them (X, XIII, XVII) by heating with acetic anhydride underwent cyclization and were transformed into the imido derivatives (XI, XIV, XVIII). Compounds XI, XIV and XVI heated with diluted aqueous solution of sodium hydroxide underwent selective hydrolysis giving the respective dicarboxylic acids XII, XV, XVII. Pharmacological analysis revealed that some of the synthesized preparations exert an anti-inflammatory effect and allow to draw limited relations between chemical structure and pharmacological activity in this group of compounds.
T Jakóbiec; I Glama; S H Kowalczyk-Bronisz; J Stankiewicz; T Zawisza
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  27     ISSN:  0004-069X     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  1979  
Date Detail:
Created Date:  1980-09-23     Completed Date:  1980-09-23     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  777-94     Citation Subset:  IM    
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MeSH Terms
Antibody Formation / drug effects
Foreign-Body Reaction / prevention & control
Guinea Pigs
Inflammation / drug therapy
Lymphocyte Activation / drug effects
Rosette Formation
Schiff Bases / chemical synthesis
Skin Tests
Structure-Activity Relationship
Thiazoles / chemical synthesis*,  pharmacology,  toxicity
Tuberculin / immunology
Reg. No./Substance:
0/Schiff Bases; 0/Thiazoles; 0/Tuberculin; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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