Document Detail

Studies on the deposition of laminin and type IV collagen in human oral mucosa transplanted to nude mice.
MedLine Citation:
PMID:  3881889     Owner:  NLM     Status:  MEDLINE    
Normal human oral mucosa (20 biopsies) and similar tissue transplanted to nude mice (44 transplants) were investigated for the presence of laminin and type IV collagen, using an indirect immunofluorescence staining technique. Laminin and type IV collagen were consistently found in the basement membrane area of the epithelial-stromal junction, and of the vessels of both normal oral mucosa and oral mucosal transplants. De novo synthesis of laminin and type IV collagen by transplanted epithelium was evidenced by the finding of an increased thickness of basement membrane deposits. New basement membrane-like material was also seen between the migrating human epithelial cells and the murine connective tissue. By application of species-specific monoclonal antibodies to human laminin and type IV collagen, it was demonstrated that human epithelial cells have the ability to participate in the information of their basement membranes. The use of both species-specific and species-unspecific antibodies showed that the vessel supply of the transplants was of both human and murine origin.
P Holmstrup
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology     Volume:  93     ISSN:  0108-0164     ISO Abbreviation:  Acta Pathol Microbiol Immunol Scand A     Publication Date:  1985 Jan 
Date Detail:
Created Date:  1985-03-14     Completed Date:  1985-03-14     Revised Date:  2009-06-04    
Medline Journal Info:
Nlm Unique ID:  8206622     Medline TA:  Acta Pathol Microbiol Immunol Scand A     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
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MeSH Terms
Basement Membrane / metabolism
Collagen / metabolism*
Fluorescent Antibody Technique
Laminin / metabolism*
Mice, Nude
Middle Aged
Mouth Mucosa / metabolism*,  transplantation
Transplantation, Heterologous
Reg. No./Substance:
0/Laminin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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