| Studies on cytotoxicity of nickel ions using C3H10T1/2 fibroblast cells. | |
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MedLine Citation:
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PMID: 11251779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cytotoxicity of Ni ions were examined using C3H mouse derived 10T1/2 fibroblast cells. It became evident that Ni ions had dose-dependent cytotoxicity. The cell number incubated in DME medium containing 0.04 mM/L Ni ion for 6 days was reduced to half that in control DME medium without Ni. The cell totally disappeared in DME medium containing 2 mM/L Ni ion. The dissolution of Ni ions from Ni-containing metallic restorations must be lower than these concentration levels so that oral tissues might not be damaged. No neoplastic transformation was found on all cells examined. |
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Authors:
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M Taira; M S Toguchi; Y Hamada; M Okazaki; J Takahashi; R Ito; S Toyosawa; N Ijyuin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of oral rehabilitation Volume: 27 ISSN: 0305-182X ISO Abbreviation: J Oral Rehabil Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-03-19 Completed Date: 2001-04-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0433604 Medline TA: J Oral Rehabil Country: England |
Other Details:
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Languages: eng Pagination: 1068-72 Citation Subset: D; IM |
Affiliation:
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Department of Dental Materials Science and Technology, Osaka University Faculty of Dentistry, Osaka, Japan. mtaira@iwate-med.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Line Cell Survival / drug effects Culture Media Dose-Response Relationship, Drug Fibroblasts / drug effects* Ions Lethal Dose 50 Mice Mice, Inbred C3H Nickel / toxicity* Nitric Acid / chemistry Sodium Bicarbonate / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Culture Media; 0/Ions; 144-55-8/Sodium Bicarbonate; 7440-02-0/Nickel; 7697-37-2/Nitric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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