Document Detail

Studies on cytotoxicity of nickel ions using C3H10T1/2 fibroblast cells.
MedLine Citation:
PMID:  11251779     Owner:  NLM     Status:  MEDLINE    
Cytotoxicity of Ni ions were examined using C3H mouse derived 10T1/2 fibroblast cells. It became evident that Ni ions had dose-dependent cytotoxicity. The cell number incubated in DME medium containing 0.04 mM/L Ni ion for 6 days was reduced to half that in control DME medium without Ni. The cell totally disappeared in DME medium containing 2 mM/L Ni ion. The dissolution of Ni ions from Ni-containing metallic restorations must be lower than these concentration levels so that oral tissues might not be damaged. No neoplastic transformation was found on all cells examined.
M Taira; M S Toguchi; Y Hamada; M Okazaki; J Takahashi; R Ito; S Toyosawa; N Ijyuin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of oral rehabilitation     Volume:  27     ISSN:  0305-182X     ISO Abbreviation:  J Oral Rehabil     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-03-19     Completed Date:  2001-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0433604     Medline TA:  J Oral Rehabil     Country:  England    
Other Details:
Languages:  eng     Pagination:  1068-72     Citation Subset:  D; IM    
Department of Dental Materials Science and Technology, Osaka University Faculty of Dentistry, Osaka, Japan.
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MeSH Terms
Cell Line
Cell Survival / drug effects
Culture Media
Dose-Response Relationship, Drug
Fibroblasts / drug effects*
Lethal Dose 50
Mice, Inbred C3H
Nickel / toxicity*
Nitric Acid / chemistry
Sodium Bicarbonate / chemistry
Reg. No./Substance:
0/Culture Media; 0/Ions; 144-55-8/Sodium Bicarbonate; 7440-02-0/Nickel; 7697-37-2/Nitric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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