Document Detail


Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals.
MedLine Citation:
PMID:  76389     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sensitization reactions to purified cinnamic aldehyde and its chemically related substances were investigated using the maximization test on guinea pigs. Mutual cross-sensitivities were also examined. Cinnamic aldehyde was found to be the most potent sensitizer in this series, and a strong cross-sensitizer. From the chemical structures of these substances, the following speculations were made. There was a tendency that as the number of hydrocarbons of alkyl groups replacing the alpha-hydrogen in the molecule increased, the rate of sensitization reaction declined. The conjugated system of double bonds was suspected to be a determinant factor in relation to the sensitization ability of the substances in this series.
Authors:
M Senma; N Fujiwara; S Sasaki; M Toyama; K Sakaguchi; I Takaoka
Related Documents :
21756989 - Inhibition of gluconeogenesis by malmea depressa root.
21713219 - Hyperthyroidism and jaundice.
872579 - Psoralen photoallergy caused by plant contact.
1901069 - Dopa reaction test in hair bulbs of fetuses and its application to the prenatal diagnos...
4113869 - Third party mixed-leukocyte culture test: a potential new method of histocompatibility ...
8024619 - Immediate hypersensitivity reaction to cyclophosphamide.
8630609 - Clinical efficacy of the amplified mycobacterium tuberculosis direct test for the diagn...
24334429 - Evaluation of a novel placental alpha microglobulin-1 (pamg-1) test to predict spontane...
12385809 - Reliability of high and low anxiety-related behaviour: influence of laboratory environm...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  58     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aldehydes / immunology*
Animals
Cinnamates / immunology*
Cross Reactions
Dermatitis, Contact*
Guinea Pigs
Immunization
Male
Skin / drug effects*
Skin Tests
Styrenes / immunology*
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Cinnamates; 0/Styrenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Immunofluorescence of the skin in allergic diseases: an investigation of patients with contact derma...
Next Document:  Drug phototoxicity in mice.