Document Detail

Studies on the cutaneous sensitization reaction of guinea pigs to purified aromatic chemicals.
MedLine Citation:
PMID:  76389     Owner:  NLM     Status:  MEDLINE    
The sensitization reactions to purified cinnamic aldehyde and its chemically related substances were investigated using the maximization test on guinea pigs. Mutual cross-sensitivities were also examined. Cinnamic aldehyde was found to be the most potent sensitizer in this series, and a strong cross-sensitizer. From the chemical structures of these substances, the following speculations were made. There was a tendency that as the number of hydrocarbons of alkyl groups replacing the alpha-hydrogen in the molecule increased, the rate of sensitization reaction declined. The conjugated system of double bonds was suspected to be a determinant factor in relation to the sensitization ability of the substances in this series.
M Senma; N Fujiwara; S Sasaki; M Toyama; K Sakaguchi; I Takaoka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  58     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1978  
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
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MeSH Terms
Aldehydes / immunology*
Cinnamates / immunology*
Cross Reactions
Dermatitis, Contact*
Guinea Pigs
Skin / drug effects*
Skin Tests
Styrenes / immunology*
Reg. No./Substance:
0/Aldehydes; 0/Cinnamates; 0/Styrenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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