Document Detail

Studies on the conversion of thyroxine to 3,5,3'-triiodothyronine in normal and thyroidectomized chickens.
MedLine Citation:
PMID:  6724289     Owner:  NLM     Status:  MEDLINE    
The possibility of conversion of L-thyroxine (T4) to L-3,5,3'-triiodothyronine (T3) and to 3,3',5'-triiodothyronine (reverse-T3, r-T3) has been investigated in chickens. Reverse-T3 could not be detected in normal animals. Both thyroidectomized and normal animals were able to convert exogenous T4 to T3. The administration of propylthiouracyl blocked this conversion to a greater extent than had been expected from the data on mammals. The conversion ratio is higher than in any other species reported in the literature. Data suggest that, as a result of the adaptation of the peripheral deiodination, thyroidectomized animals were able to convert more T4 to T3 than were normal ones.
P Rudas; G Pethes
Related Documents :
11521499 - Nitrous acid interference with passive no2 measurement methods and the impact on indoor...
12375839 - Chemiluminescence biosensor chip based on a microreactor using carrier air flow for det...
1275069 - Use of pyrazinamide to assess renal uric acid transport in the rat: a micropuncture study.
2437269 - Respiratory clearance of aerosolized radioactive solutes of varying molecular weight.
6835909 - Variation in the potassium needs of chickens selected genetically for variation in bloo...
20035639 - Uric acid is not an independent predictor of cardiovascular death in patients with angi...
19909499 - Oral high dose ascorbic acid treatment for one year in young cmt1a patients: a randomis...
3259739 - Effect of tetrahydrobiopterin and 5-hydroxytryptophan on hereditary progressive dystoni...
7615579 - Nitric acid passivation of ti6al4v reduces thickness of surface oxide layer and increas...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  54     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-02     Completed Date:  1984-07-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Metabolic Clearance Rate
Propylthiouracil / pharmacology
Thyroxine / metabolism*
Triiodothyronine / biosynthesis*
Reg. No./Substance:
51-52-5/Propylthiouracil; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Galactogen synthesis-stimulating factor in the slug, Limax maximus: cellular localization and partia...
Next Document:  The effects of estrogen on skeletal calcium metabolism and on plasma parameters of vitellogenesis in...