Document Detail


Studies on the conversion of thyroxine to 3,5,3'-triiodothyronine in normal and thyroidectomized chickens.
MedLine Citation:
PMID:  6724289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The possibility of conversion of L-thyroxine (T4) to L-3,5,3'-triiodothyronine (T3) and to 3,3',5'-triiodothyronine (reverse-T3, r-T3) has been investigated in chickens. Reverse-T3 could not be detected in normal animals. Both thyroidectomized and normal animals were able to convert exogenous T4 to T3. The administration of propylthiouracyl blocked this conversion to a greater extent than had been expected from the data on mammals. The conversion ratio is higher than in any other species reported in the literature. Data suggest that, as a result of the adaptation of the peripheral deiodination, thyroidectomized animals were able to convert more T4 to T3 than were normal ones.
Authors:
P Rudas; G Pethes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  54     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-02     Completed Date:  1984-07-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  154-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Chickens
Metabolic Clearance Rate
Propylthiouracil / pharmacology
Thyroidectomy*
Thyroxine / metabolism*
Triiodothyronine / biosynthesis*
Chemical
Reg. No./Substance:
51-52-5/Propylthiouracil; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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