Document Detail


Studies of the clinical pharmacology and therapeutic efficacy of pentoxifylline in peripheral obstructive arterial disease.
MedLine Citation:
PMID:  6540539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Studies were carried out to investigate the effects of pentoxifylline on various hemorheological (whole blood, plasma and serum viscosity, erythrocyte filtrability, hematocrit), hemostasiological (blood coagulation and fibrinolysis: euglobulin lysis time, fibrinogen, plasminogen, alpha-2-macroglobulin, alpha-1-antitrypsin, antiplasmin; platelet function: beta-thromboglobulin), and hemodynamic factors (limb perfusion: rest and peak flow, time to peak flow; systemic blood pressure, heart rate). In addition, clinical efficacy was monitored in patients with claudication by assessing walking capacity under placebo controlled double blind cross over conditions. The investigations disclosed the positive influence of acute and chronic pentoxifylline administration on hemorheological, hemostasiological and perfusion parameters, most of the changes recorded being statistically significant. The clinical benefit of pentoxifylline (Trental 400) treatment was demonstrated by the significantly superior increase in walking capacity in comparison to placebo in the controlled study.
Authors:
T Di Perri; O Carandente; A Vittoria; M Guerrini; G L Messa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Angiology     Volume:  35     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1984 Jul 
Date Detail:
Created Date:  1984-09-12     Completed Date:  1984-09-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  427-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Alprostadil
Animals
Antifibrinolytic Agents / therapeutic use
Arterial Occlusive Diseases / drug therapy*
Blood Platelets / physiology
Drug Synergism
Fibrinolysis / drug effects*
Leg / blood supply
Locomotion / drug effects
Macaca
Male
Pentoxifylline / therapeutic use*
Prostaglandins E / therapeutic use
Regional Blood Flow
Rheology
Theobromine / analogs & derivatives*
Urokinase-Type Plasminogen Activator / therapeutic use
Chemical
Reg. No./Substance:
0/Antifibrinolytic Agents; 0/Prostaglandins E; 6493-05-6/Pentoxifylline; 745-65-3/Alprostadil; 83-67-0/Theobromine; EC 3.4.21.73/Urokinase-Type Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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