Document Detail

Studies on chiasma frequency and distribution in two fertile men carrying reciprocal translocations; one with a t(9;10) karyotype and one with a t(Y;10) karyotype.
MedLine Citation:
PMID:  6500577     Owner:  NLM     Status:  MEDLINE    
The frequency and distribution of chiasmata was investigated in two fertile carriers of reciprocal translocations, one with a 46,XY,t(9;10)(p22;q24) karyotype and one with a 46,X,-Y,+der(Y),t(Y;10)(q12;q24) karyotype. In both cases the chromosomes involved in the translocation showed an increase in chiasma frequency in comparison to karyotypically normal controls and in both cases this increase was localised, affecting only one interstitial segment of each translocation quadrivalent. In the t(9;10) case chiasmata appeared in substantial numbers in a novel location, the proximal two thirds of 9p, while in the t(Y;10) case chiasmata appeared in a conventional location, the medial region of 10q, but at an increased frequency. Furthermore there was evidence for inter-chromosomal effects in the t(9;10) case.
D A Laurie; R W Palmer; M A Hultén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  68     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1984  
Date Detail:
Created Date:  1985-01-22     Completed Date:  1985-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  235-47     Citation Subset:  IM    
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MeSH Terms
Chromosomes, Human, 6-12 and X*
Crossing Over, Genetic*
Sex Chromosome Aberrations / genetics*
Translocation, Genetic*
Y Chromosome*

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