| Studies on cell surface conformation following injury. II. Scanning and transmission electron microscopy of cell surface changes following anoxic injury in Ehrlich ascites tumor cells. | |
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MedLine Citation:
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PMID: 105466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Exposure of Ehrlich ascites tumor cells to anoxia resulted in rapid and characteristic conformational changes of cell surface topography. Combined scanning and transmission E/M studies revealed rapid alterations including simplification of the cell surface configuration with disappearance of microvilli which were replaced with formation of blebs and recesses at the cell periphery. These surface changes were accompanied by characteristic organelle alterations inside the cells which in this and other cellular systems have been shown to be reversible. Later, the cell surface topography became smoother and monotonic with small blebs and cribriform invaginations in addition to larger eruptions of the cell periphery. Combined transmission E/M studies revealed fragmentation of cellular membrane systems and lysis of organelles indicating the irreversible phase of anoxic injury. The rapid conformational surface changes encountered in Ehrlich ascites tumor cells following anoxia suggest the important role of the plasma membrane and its unfolding as a virtually instantaneous response of the cells to this injury. |
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Authors:
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B F Trump; A Penttila; I K Berezesky |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Virchows Archiv. B: Cell pathology Volume: 29 ISSN: 0340-6075 ISO Abbreviation: Virchows Arch B Cell Pathol Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0437105 Medline TA: Virchows Arch B Cell Pathol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 297-307 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / pathology* Carcinoma, Ehrlich Tumor / ultrastructure* Cell Membrane / ultrastructure Mice Microscopy, Electron Microscopy, Electron, Scanning Microvilli / ultrastructure Time Factors |
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