Document Detail

Studies on cell surface conformation following injury. II. Scanning and transmission electron microscopy of cell surface changes following anoxic injury in Ehrlich ascites tumor cells.
MedLine Citation:
PMID:  105466     Owner:  NLM     Status:  MEDLINE    
Exposure of Ehrlich ascites tumor cells to anoxia resulted in rapid and characteristic conformational changes of cell surface topography. Combined scanning and transmission E/M studies revealed rapid alterations including simplification of the cell surface configuration with disappearance of microvilli which were replaced with formation of blebs and recesses at the cell periphery. These surface changes were accompanied by characteristic organelle alterations inside the cells which in this and other cellular systems have been shown to be reversible. Later, the cell surface topography became smoother and monotonic with small blebs and cribriform invaginations in addition to larger eruptions of the cell periphery. Combined transmission E/M studies revealed fragmentation of cellular membrane systems and lysis of organelles indicating the irreversible phase of anoxic injury. The rapid conformational surface changes encountered in Ehrlich ascites tumor cells following anoxia suggest the important role of the plasma membrane and its unfolding as a virtually instantaneous response of the cells to this injury.
B F Trump; A Penttila; I K Berezesky
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Virchows Archiv. B: Cell pathology     Volume:  29     ISSN:  -     ISO Abbreviation:  Virchows Arch B Cell Pathol     Publication Date:  1979 Feb 
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  0437105     Medline TA:  Virchows Arch B Cell Pathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  297-307     Citation Subset:  IM    
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MeSH Terms
Anoxia / pathology*
Carcinoma, Ehrlich Tumor / ultrastructure*
Cell Membrane / ultrastructure
Microscopy, Electron
Microscopy, Electron, Scanning
Microvilli / ultrastructure
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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