| Studies on cancer chemoprevention by traditional folk medicines XXIV. Inhibitory effect of a coumarin derivative, 7-isopentenyloxycoumarin, against tumor-promotion. | |
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MedLine Citation:
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PMID: 11853175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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7-Isopentenyloxycoumarin (1) was isolated from Heracleum lanatum MICHX. (Umbelliferae). Compound 1 inhibited phospholipid metabolism and Epstein-Barr virus activation caused by a potent tumor promoter. In an in vivo experiment, topical application of 1 suppressed skin-tumor-formation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene (DMBA) initiated mice. And it also suppressed ornithine decarboxylase activity stimulated by TPA on mouse skin. These results indicated that 7-isopentenyloxycoumarin is one of the effective compounds from natural resources for treating skin tumor formation. |
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Authors:
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Masaki Baba; Yongri Jin; Atsuo Mizuno; Hisaya Suzuki; Yoshihito Okada; Nobuo Takasuka; Harukuni Tokuda; Hoyoku Nishino; Toru Okuyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 25 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-20 Completed Date: 2002-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 244-6 Citation Subset: IM |
Affiliation:
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Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, Kiyose, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticarcinogenic Agents / pharmacology* Antineoplastic Agents, Phytogenic / pharmacology* Coumarins / pharmacology* Female Hela Cells Heracleum* Herpesvirus 4, Human / drug effects Humans Mice Mice, Inbred ICR Ornithine Decarboxylase / antagonists & inhibitors Phytotherapy* Skin Neoplasms / chemically induced, prevention & control Virus Activation / drug effects |
| Chemical | |
Reg. No./Substance:
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0/7-isopentenyloxycoumarin; 0/Anticarcinogenic Agents; 0/Antineoplastic Agents, Phytogenic; 0/Coumarins; EC 4.1.1.17/Ornithine Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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