Document Detail


Studies on the antimycotic activity of 5-fluoroorotic acid.
MedLine Citation:
PMID:  3586772     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antimycotic effect of 5-fluoroorotic acid (FOA) was studied in experimental and clinical conditions. The experiments in vitro were performed on 21 strains of fungi isolated mainly from clinical material. The effect of FOA was compared with those of the structurally related drug 5-fluorocytosine. The clinical study was performed on 40 patients aged 18 to 75 years with mycological diseases. FOA in different dosage forms was applied topically 2 to 3 times daily for 30 days. Microscopic and cultured mycological studies were performed before and after treatment. The results showed that FOA possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects. Clinical studies of 1% FOA cream showed good therapeutic effects similar to that of Ung. Whitfield, but 55% of the patients developed relapse of the lesions after discontinuation of the treatment. Higher concentrations of FOA included in milk suspension and powder induced severe side effects of local irritability.
Authors:
K Nikolova; L Maneva; G Karamanov; E Golovinsky
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  9     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Antifungal Agents*
Arthrodermataceae / drug effects*
Candida / drug effects*
Dermatomycoses / drug therapy*
Female
Flucytosine / pharmacology
Humans
Liniments
Male
Mice
Microbial Sensitivity Tests
Middle Aged
Ointments
Orotic Acid / analogs & derivatives*,  pharmacology
Powders
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Liniments; 0/Ointments; 0/Powders; 2022-85-7/Flucytosine; 65-86-1/Orotic Acid; 703-95-7/5-fluoroorotic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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