| Studies on the antimycotic activity of 5-fluoroorotic acid. | |
MedLine Citation:
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PMID: 3586772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antimycotic effect of 5-fluoroorotic acid (FOA) was studied in experimental and clinical conditions. The experiments in vitro were performed on 21 strains of fungi isolated mainly from clinical material. The effect of FOA was compared with those of the structurally related drug 5-fluorocytosine. The clinical study was performed on 40 patients aged 18 to 75 years with mycological diseases. FOA in different dosage forms was applied topically 2 to 3 times daily for 30 days. Microscopic and cultured mycological studies were performed before and after treatment. The results showed that FOA possesses a well-expressed anticandidal effect close to that of 5-fluorocytosine, as well as moderate antidermatophytal effects. Clinical studies of 1% FOA cream showed good therapeutic effects similar to that of Ung. Whitfield, but 55% of the patients developed relapse of the lesions after discontinuation of the treatment. Higher concentrations of FOA included in milk suspension and powder induced severe side effects of local irritability. |
Authors:
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K Nikolova; L Maneva; G Karamanov; E Golovinsky |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods and findings in experimental and clinical pharmacology Volume: 9 ISSN: 0379-0355 ISO Abbreviation: Methods Find Exp Clin Pharmacol Publication Date: 1987 Feb |
Date Detail:
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Created Date: 1987-06-26 Completed Date: 1987-06-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909595 Medline TA: Methods Find Exp Clin Pharmacol Country: SPAIN |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Animals Antifungal Agents* Arthrodermataceae / drug effects* Candida / drug effects* Dermatomycoses / drug therapy* Female Flucytosine / pharmacology Humans Liniments Male Mice Microbial Sensitivity Tests Middle Aged Ointments Orotic Acid / analogs & derivatives*, pharmacology Powders |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 0/Liniments; 0/Ointments; 0/Powders; 2022-85-7/Flucytosine; 65-86-1/Orotic Acid; 703-95-7/5-fluoroorotic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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