Document Detail

Studies on antidiarrhoeal activity of Punica granatum seed extract in rats.
MedLine Citation:
PMID:  10624879     Owner:  NLM     Status:  MEDLINE    
Methanol extract of Punica granatum seed was evaluated for antidiarrhoeal activity against different experimental models of diarrhoea in rats. P. granatum seed extract treated animals showed significant inhibitory activity against castrol-oil induced diarrhoea and PGE2 induced enteropooling in rats. The extract also showed a significant reduction in gastro-intestinal motility in charcoal meal test in rats. The results obtained established the efficacy of P. granatum seed extract as an antidiarrhoeal agent.
A K Das; S C Mandal; S K Banerjee; S Sinha; J Das; B P Saha; M Pal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  68     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-02-28     Completed Date:  2000-02-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Department of Pharmaceutical Technology, Faculty of Engineering and Technology, Jadavpur University, Calcutta, India.
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MeSH Terms
Antidiarrheals / therapeutic use*
Castor Oil / adverse effects
Dinoprostone / adverse effects
Gastrointestinal Motility / drug effects
Medicine, Traditional
Plant Extracts / therapeutic use*
Rats, Wistar
Reg. No./Substance:
0/Antidiarrheals; 0/Plant Extracts; 363-24-6/Dinoprostone; 8001-79-4/Castor Oil

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