| Studies on aldose reductase inhibitors from natural products. II. Active components of a Paraguayan crude drug "Para-parai mí," Phyllanthus niruri. | |
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MedLine Citation:
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PMID: 2514047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. |
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Authors:
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M Shimizu; S Horie; S Terashima; H Ueno; T Hayashi; M Arisawa; S Suzuki; M Yoshizaki; N Morita |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 37 ISSN: 0009-2363 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1990-02-22 Completed Date: 1990-02-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 2531-2 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehyde Reductase
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antagonists & inhibitors* Animals Paraguay Plants, Medicinal / analysis* Rats Sugar Alcohol Dehydrogenases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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EC 1.1.-/Sugar Alcohol Dehydrogenases; EC 1.1.1.21/Aldehyde Reductase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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