| Studies on acid-base status (Stewart's model) of young camels (Camelus dromedarius) after acid-load with NH4Cl. | |
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MedLine Citation:
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PMID: 20329648 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of the reference values of Stewart variables and the changes in the acid-base status of the blood and urine in relation to the age after acid-load were studied in desert species of camels. 14 healthy young camels (age: 3-5 months) and 22 adult camels (age: 5-8 years) were used to provide the reference and percentile ranges of the Stewart variables. In the experiments, 24 healthy young camels (age: < 3-5 months) were infused with 5M NH4Cl solution (dose: 1.0 ml/kg) through a permanent intravenous catheter. Venous blood and urine samples were collected before infusion (0 hours). After the start of infusion, venous blood samples were collected at 2, 4, 6, 8 and 24 hours, and urine samples were collected at 8, 24 and 48 hours. Blood and urine samples were used for the determination of the various acid-base parameters, including the non-respiratory Stewart variables. The reference range of serum-[strong ion difference = SID3] was 39-52 mmol/l for all age groups. The reference values of serum-[acid total = A-] were between 10-17 mmol/l for all age groups. Serum-[Atotprotein] and -[Atot-albumin] showed a reference range of 19-24 mmol/I and 20-28 mmol/l, respectively. By 2-8 hours after the NH4Cl-load, the Stewart variables (serum-[SID3] and serum-[A(tot-protein)]) decreased significantly, and as a consequence, the blood pH decreased. Generally, the loaded young camels showed a transient moderate hyperchloraemic acidosis with a slight hypoproteinaemic alkalosis. These malfunctions were accompanied by increased renal fractional excretion of chloride and sodium and decreased urine pH. CONCLUSION: The identified reference values of the Stewart variables can be used for the clinical diagnosis of acid-base disturbances in camels. With the assistance of the non-respiratory Stewart variables ([SID3] and [Atot]), we can detect the determining influence of strong electrolytes (Na+, K+ and Cl-) and weak acids (proteins, Pi) on the physiological and pathological acid-base status of the animals. |
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Authors:
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Nawal M Elkhair; Helmut Hartmann |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Berliner und M?nchener tier?rztliche Wochenschrift Volume: 123 ISSN: 0005-9366 ISO Abbreviation: Berl. Munch. Tierarztl. Wochenschr. Publication Date: 2010 Mar-Apr |
Date Detail:
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Created Date: 2010-03-24 Completed Date: 2010-04-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0003163 Medline TA: Berl Munch Tierarztl Wochenschr Country: Germany |
Other Details:
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Languages: eng Pagination: 153-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Veterinary Medicine, University of Khartoum, Sudan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects,
physiology Acid-Base Imbalance / blood, diagnosis, veterinary* Aging / drug effects Ammonium Chloride / pharmacology* Animals Camels / blood, physiology* Female Male Reference Values |
| Chemical | |
Reg. No./Substance:
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12125-02-9/Ammonium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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