Document Detail


Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VI. The decomposition products of ginsenoside Rb2 in the stomach of rats.
MedLine Citation:
PMID:  2054864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The decomposition of ginsenoside Rb2 (Rb2) in rat stomach (in vivo) and in 0.1 N HCl solution (in vitro) was investigated in detail. By treating with 0.1 N HCl, the acidity of which is similar to that of gastric juice, a part of Rb2 was hydrolyzed to 20(R,S)-ginsenoside Rg3. On the other hand, Rb2 was little decomposed in rat stomach and a small quantity of an unidentified metabolite, which was different from the hydrolyzed products in 0.1 N HCl, was observed. The metabolite was separated into four compounds, which were identified by 1H- and 13C-nuclear magnetic resonance and fast atom bombardment mass spectrometry. These compounds were determined to be 25-hydroxy-23-ene (IV), 24-hydroxy-25-ene (V), 25-hydroperoxy-23-ene (VI) and 24-hydroperoxy-25-ene (VII) derivative of Rb2, respectively. In this study, it is suggested that 20(S)-protopanaxatriol saponins undergo hydrolysis of the C-20 glycosyl moiety and hydration of the side chain, on the other hand, 20(S)-protopanaxadiol saponins undergo oxygenation of the side chain.
Authors:
M Karikura; T Miyase; H Tanizawa; T Taniyama; Y Takino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  39     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-07-26     Completed Date:  1991-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  400-4     Citation Subset:  IM    
Affiliation:
School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Biotransformation
Ginsenosides*
Rats
Saponins / metabolism,  pharmacokinetics*
Stomach / metabolism*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Ginsenosides; 0/Saponins; 11021-13-9/ginsenoside Rb2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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