| Studies of severe acute respiratory syndrome coronavirus pathology in human cases and animal models. | |
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MedLine Citation:
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PMID: 20664013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the severe acute respiratory syndrome (SARS) outbreak of 2003, approximately 10% of SARS patients developed progressive respiratory failure and died. Since then, several animal models have been established to study SARS coronavirus, with the aim of developing new antiviral agents and vaccines. This short review describes the pathologic features of SARS in relation to their clinical presentation in human cases. It also looks at animal susceptibility after experimental infection, animal models of SARS, and the pathogenesis of this disease. It seems that adaptation of the virus within the host animal and the subsequent abnormal immune responses may be key factors in the pathogenesis of this new and fatal respiratory disease. The proteases produced in the lung during inflammation could also play an important role for exacerbation of SARS in animals. |
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Authors:
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N Nagata; N Iwata-Yoshikawa; F Taguchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-27 |
Journal Detail:
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Title: Veterinary pathology Volume: 47 ISSN: 1544-2217 ISO Abbreviation: Vet. Pathol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0312020 Medline TA: Vet Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 881-92 Citation Subset: IM |
Affiliation:
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DVM, PhD, Department of Pathology, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-murayama, Tokyo, Japan, 208-0011.nnagata@nih.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Laboratory Animals, Wild Disease Models, Animal Disease Outbreaks* Humans Lung / immunology, pathology, virology* SARS Virus / immunology* Severe Acute Respiratory Syndrome / immunology*, pathology, virology |
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