| Studies on Scavenger Receptors under Experimental Hypercholesterolemia: Modulation on Selenium Supplementation. | |
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MedLine Citation:
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PMID: 20852967 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Scavenger receptors (SR) are the cell surface proteins that can bind and internalize modified lipoproteins. Because ox-LDL seems to play a key role in foam cell formation during atherogenesis, SR may be critical for pathogenesis of atherosclerosis. The present study was aimed to study the effect of selenium (Se) supplementation on SR, i.e., SRB1 and CD36 under experimental hypercholesterolemia. Male Sprague Dawley rats were divided into three groups and fed on the control diet, high cholesterol diet (HCD), and HCD + Se, respectively, for a period of 4 months. Selenium and reactive oxygen species (ROS) levels were estimated in serum and liver respectively. mRNA expression using RT-PCR and protein expression using ELISA were analyzed for SRB1 and CD36 receptors. Selenium levels decreased whereas ROS levels increased under experimental hypercholesterolemic state. Selenium supplementation (1 ppm), however, diminished the HCD-induced ROS levels. Furthermore, the protein expression of SRB1 was significantly reduced in HCD group in comparison to the control group. On the other hand, HCD-induced increase in CD36 mRNA and protein expression decreased significantly on Se supplementation. In conclusion, CD36 receptors seem to play a pro-atherogenic role under hypercholesterolemic state. Selenium supplementation, in addition, might prove to be a therapeutically valuable approach in near future to limit the adverse effect of hypercholesterolemia. |
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Authors:
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Harmandeep Kaur; Mohinder P Bansal |
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Publication Detail:
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Type: Journal Article Date: 2010-09-18 |
Journal Detail:
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Title: Biological trace element research Volume: 143 ISSN: 1559-0720 ISO Abbreviation: Biol Trace Elem Res Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7911509 Medline TA: Biol Trace Elem Res Country: United States |
Other Details:
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Languages: eng Pagination: 310-9 Citation Subset: IM |
Affiliation:
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Department of Biophysics, Panjab University, Chandigarh, 160014, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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