| Studies on the Na+-K+-ATPase in myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 6271994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Changes in the cardiac sarcolemma in myocardial infarction were studied by both determination of Na+-K+-ATPase activity and SDS gel electrophoretic analysis of sarcolemmal proteins in the canine heart. Ninety minutes after coronary ligation, Na+-K+-ATPase activity in ischemic myocardium was decreased significantly to approximately 36% of that of non-ischemic myocardium, and it remained at the lower level for 28 days. By SDS gel electrophoresis, reduction of the protein band with molecular weight of 111,000, which is suggestive of the main component of ATPase, was observed simultaneously with the reduction of Na+-K+-ATPase activity. These results indicate that ischemia for 90 minutes produces substructural changes in the sarcolemma indicating irreversible myocardial changes. |
| | |
Authors:
|
Y Kobayashi; Y Sasai; N Nakamura; T Katagiri |
Related Documents
:
|
19075664 - Alternative pharmacological interventions that limit myocardial infarction. 9130454 - The early and late phases of ischemic preconditioning: a comparative analysis of their ... 15913644 - Preinfarction angina: no interference of coronary microembolization with acute ischemic... 9436564 - Failure of preconditioning to improve postcardioplegia stunning of minimally infarcted ... 9894704 - Changing prescribing behaviour: early low dose aspirin in suspected acute myocardial in... 19442954 - Left ventricular torsion: an expanding role in the analysis of myocardial dysfunction. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Japanese circulation journal Volume: 45 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1981 Nov |
Date Detail:
|
Created Date: 1982-01-09 Completed Date: 1982-01-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
|
Languages: eng Pagination: 1256-63 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Vessels / surgery Dogs Ligation Myocardial Infarction / enzymology* Myocardium / enzymology Sarcolemma / enzymology Sodium-Potassium-Exchanging ATPase / metabolism* |
| Chemical | |
Reg. No./Substance:
|
EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Perirectal infections in patients with small cell lung cancer.
Next Document: Histochemical study on 5'-nucleotidase in the cerebrovascular system in stroke-prone spontaneously h...