Document Detail

Studies on LHRH and physiological fluid amino acids in human colostrum and milk.
MedLine Citation:
PMID:  3552619     Owner:  NLM     Status:  MEDLINE    
Various physiological fluid amino acids including essential, nonessential and neuroinhibitory as well as excitatory entities in human milk, colostrum, and infant formula were determined on a microcolumn ion-exchange analyzer equipped with ninhydrin detection system and integrator. The levels of 6 essential and 6 nonessential amino acids were significantly lower in infant formula than those in milk and colostrum. The neurotransmitter amino acids were also high in milk except taurine. Peptide hormones like LHRH were undetectable in infant formula, but were found in appreciable quantities in milk and colostrum by high pressure liquid chromatography. LHRH levels in milk were 6 to 7 fold higher than the corresponding plasma values as measured by radioimmunoassay. These and other several unique ingredients in human breast milk play a very prominent role in the development of the neonate. The presence of such complex components makes it impossible to humanize cow's milk or any other alternate formulation and to serve as a substitute for human milk. Further extensive work in defining the role of such essential components in milk on the development of the infant is indicated.
R M Nair; M Somasundaran; L D Katikaneni; D M Purohit
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Endocrinologia experimentalis     Volume:  21     ISSN:  0013-7200     ISO Abbreviation:  Endocrinol. Exp.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-16     Completed Date:  1987-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0125712     Medline TA:  Endocrinol Exp     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  23-30     Citation Subset:  IM    
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MeSH Terms
Amino Acids / analysis*
Ammonia / analysis
Chromatography, High Pressure Liquid
Colostrum / analysis*
Gonadotropin-Releasing Hormone / analysis*
Infant Food / analysis
Milk, Human / analysis*
Reg. No./Substance:
0/Amino Acids; 33515-09-2/Gonadotropin-Releasing Hormone; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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