Document Detail

Studies of HLA, fertility and mate choice in a human isolate.
MedLine Citation:
PMID:  10336015     Owner:  NLM     Status:  MEDLINE    
The role of human leukocyte antigen (HLA) genes in pregnancy and in human mate choice has been investigated in the Hutterites, an inbred population of European origins. High-resolution HLA haplotypes were defined by alleles at 16 loci in >1000 Hutterites. Prospective studies of pregnancy outcome previously demonstrated increased fetal loss rates among Hutterite couples matching for HLA-B antigens (P = 0.033) or for the entire 16-locus haplotype (P = 0.002). Among living children of couples matching for HLA-B or for the haplotype, there was a non-significant deficit of children who were heterozygous and compatible with the mother; the number of living children who were compatible and homozygous or incompatible and heterozygous was not different than expectations (HLA-B, P = 0.095; haplotype, P = 0.376). Mate choice among 411 couples was non-random with respect to the HLA haplotype, assessed by a variety of methods (P = 0.020 to <0.001). These combined data indicate a role for HLA region genes in both pregnancy outcome and mate choice, and suggest that selection acting on these genes occurs pre-conceptually as well as during pregnancy. This review outlines previously published studies on HLA, fertility and mate choice in the Hutterites.
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Human reproduction update     Volume:  5     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    1999 Mar-Apr
Date Detail:
Created Date:  1999-07-13     Completed Date:  1999-07-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  103-7     Citation Subset:  IM    
Department of Human Genetics, University of Chicago, IL 60615, USA.
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MeSH Terms
Fertility / genetics*,  immunology
Genetics, Population
HLA Antigens / genetics*,  immunology
Pregnancy Outcome*
Prospective Studies
Grant Support
Reg. No./Substance:
0/HLA Antigens

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