| Studies on Fletcher trait and Fitzgerald trait. A rare chance to disclose body's defense reactions against injury. | |
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MedLine Citation:
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PMID: 20838736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The way by which contact of blood with foreign surface accelerates clotting has been elucidated from the discovery of four rare disorders of blood coagulation; Hageman trait, plasma thromboplastin antecedent (PTA) deficiency, Fletcher trait, and Fitzgerald trait. Interestingly, it was unexpectedly found that Fletcher factor is plasma prekallikrein and Fitzgerald factor is high-molecular-weight kininogen; components of the kinin-generating system, thus disclosing intimate relationships among clotting, fibrinolysis and kinin generation which may be viewed as body's defense reactions against injury. This review mainly reflects our research on Fletcher trait and Fitzgerald trait during the 1970s in Cleveland. |
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Authors:
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Hidehiko Saito |
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Publication Detail:
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Type: Historical Article; Journal Article; Portraits; Review Date: 2010-09-13 |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 104 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: 2011-04-08 Revised Date: 2011-05-23 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: Germany |
Other Details:
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Languages: eng Pagination: 867-74 Citation Subset: IM |
Affiliation:
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Nagoya Central Hospital, Nagoya, Japan. hidehiko.saito@jr-central.co.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Coagulation Disorders, Inherited / blood, genetics, history* Blood Coagulation Tests / history Hematology / history* Hemostasis* / genetics History, 20th Century Humans Kininogen, High-Molecular-Weight / genetics, history*, metabolism Prekallikrein / genetics, history*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Kininogen, High-Molecular-Weight; 9055-02-1/Prekallikrein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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