| Studies on the Cu(I)-catalyzed regioselective anti-carbometallation of secondary terminal propargylic alcohols. | |
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MedLine Citation:
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PMID: 16555817 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A highly regioselective Cu(I)-catalyzed anti-carbometallation of secondary terminal propargylic alcohols with 1 degrees alkyl or aryl Grignard reagents affording 2-substituted allylic alcohols was developed. By using this method, optically active allylic alcohols can be prepared from the optically active propargylic alcohols without obvious loss of the enantiopurity. The cyclic organometallic intermediate formed may undergo an iodination or a Pd(0)-catalyzed coupling reaction to afford stereo-defined allylic alcohols. |
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Authors:
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Zhan Lu; Shengming Ma |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of organic chemistry Volume: 71 ISSN: 0022-3263 ISO Abbreviation: J. Org. Chem. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-24 Completed Date: 2007-01-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985193R Medline TA: J Org Chem Country: United States |
Other Details:
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Languages: eng Pagination: 2655-60 Citation Subset: - |
Affiliation:
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Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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