Document Detail

Studies of the CAG repeat in the Machado-Joseph disease gene in Taiwan.
MedLine Citation:
PMID:  9254842     Owner:  NLM     Status:  MEDLINE    
Machado-Joseph disease (MJD) is an autosomal dominant spinocerebellar degeneration characterized by cerebellar ataxia and pyramidal signs associated in varying degrees with a dystonic-rigid extrapyramidal syndrome or peripheral amyotrophy. Unstable CAG trinucleotide repeat expansion in the MJD gene on the long arm of chromosome 14 has been identified as the pathological mutation for MJD. While investigating the distribution of CAG repeat lengths of the MJD gene in Taiwan's population, we have identified 18 MJD-affected patients and 12 at-risk individuals in seven families. In addition, we have analyzed the range of CAG repeat lengths in 96 control individuals. The CAG repeat number ranged from 13 to 44 in the controls and 72-85 in the affected and at-risk individuals. Our results indicated that the CAG repeat number was inversely correlated with the age of onset. The differences in CAG repeat length between parent and child and between siblings are greater with paternal transmission than maternal transmission. Our data show a tendency towards the phenomenon of anticipation in the MJD families but do not support unidirectional expansion of CAG repeats during transmission. We also demonstrated that PCR amplification of the CAG repeats in the MJD gene from villous DNA was possible and might prove useful as a diagnostic tool for affected families in the future.
M Hsieh; H F Tsai; T M Lu; C Y Yang; H M Wu; S Y Li
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  100     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-08     Completed Date:  1997-09-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  155-62     Citation Subset:  IM    
Institute of Medicine, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
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MeSH Terms
Age of Onset
Asian Continental Ancestry Group / genetics*
China / ethnology
Chorionic Villi
Genetic Testing
Linear Models
Machado-Joseph Disease / diagnosis,  epidemiology,  etiology,  genetics*
Middle Aged
Prenatal Diagnosis
Taiwan / epidemiology
Trinucleotide Repeats*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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