Document Detail

Studies on Alismatis rhizoma. I. Anti-allergic effects of methanol extract and six terpene components from Alismatis rhizoma (dried rhizome of Alisma orientale).
MedLine Citation:
PMID:  9178931     Owner:  NLM     Status:  MEDLINE    
Methanol and aqueous extracts (TMe-ext and TAq-ext) from dried rhizomes of Alisma orientale have been screened for activity in experimental models of type I-IV allergies. In the type III allergic model, TMe-ext at oral doses of 50, 200 mg/kg showed an inhibitory effect on the direct passive Arthus reaction (DPAR) in rats, while TAq-ext did not. Four triterpenes (alisol A, alisol B, alisol A monoacetate and alisol B monoacetate) and two sesquiterpenes (alismol and alismoxide) isolated from TMe-ext also exhibited this inhibitory effect. In a type I allergic model, TMe-ext inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats. In a type II allergic model, it was found that TMe-ext inhibits reversed cutaneous anaphylaxis (RCA) in rats. Furthermore, in a type IV allergic model, TMe-ext had an inhibitory effect on the induction phase in picryl chloride-induced contact dermatitis (PC-CD) in mice. These results indicate that Alismatis Rhizoma not only inhibits antibody-mediated allergic reactions but also influences cell reactions and should be recognized as a material for the treatment of allergic reactions, and the anti-type III allergic components are partially attributable to the terpenes mentioned above.
M Kubo; H Matsuda; N Tomohiro; M Yoshikawa
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  20     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  511-6     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan.
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MeSH Terms
Anti-Allergic Agents / pharmacology*
Arthus Reaction / prevention & control
Dermatitis, Allergic Contact / prevention & control
Drugs, Chinese Herbal / pharmacology*
Hypersensitivity / prevention & control*
Mice, Inbred ICR
Passive Cutaneous Anaphylaxis / drug effects
Rats, Sprague-Dawley
Rats, Wistar
Terpenes / isolation & purification,  pharmacology*
Reg. No./Substance:
0/Anti-Allergic Agents; 0/Drugs, Chinese Herbal; 0/Terpenes; 67-56-1/Methanol

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