Document Detail


Student screening for inherited blood disorders in Bahrain.
MedLine Citation:
PMID:  15751927     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In Bahrain and neighbouring countries inherited disorders of haemoglobin, i.e. sickle-cell disease, thalassaemias and glucose-6-phosphate dehydrogenase (G6PD) deficiency, are common. As part of the National Student Screening Project to determine the prevalence of genetic blood disorders and raise awareness among young Bahrainis, we screened 11th-grade students from 38 schools (5685 students), organized lectures and distributed information about these disorders. Haemoglobin electrophoresis, high performance liquid chromatography, blood grouping and G6PD deficiency testing were performed. Prevalences were: 1.2% sickle-cell disease; 13.8% sickle-cell trait; 0.09% beta-thalassaemia; 2.9% beta-thalassaemia trait; 23.2% G6PD deficiency; 1.9% G6PD deficiency carrier. Health education, carrier screening and premarital counselling remain the best ways to reduce disease incidence with potentially significant financial savings and social and health benefits.
Authors:
S Al-Arrayed; N Hafadh; S Amin; H Al-Mukhareq; H Sanad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  9     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:  2003 May 
Date Detail:
Created Date:  2005-03-08     Completed Date:  2005-04-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  344-52     Citation Subset:  IM    
Affiliation:
Genetics Unit, Salmaniya Medical Complex, Manama, Bahrain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anemia, Sickle Cell / diagnosis,  epidemiology*,  genetics,  prevention & control
Bahrain / epidemiology
Consanguinity
Female
Genetic Counseling
Genetic Testing / organization & administration*
Glucosephosphate Dehydrogenase Deficiency / diagnosis,  epidemiology*,  genetics,  prevention & control
Health Education
Health Services Needs and Demand
Hemoglobin C Disease / diagnosis,  epidemiology,  genetics,  prevention & control
Hemoglobin E
Hemoglobinopathies / diagnosis,  epidemiology,  genetics,  prevention & control
Hemoglobins, Abnormal
Heterozygote Detection
Humans
Male
Mutation / genetics
Population Surveillance
Prevalence
School Health Services / organization & administration*
Sickle Cell Trait / diagnosis,  epidemiology*,  genetics,  prevention & control
Thalassemia / diagnosis,  epidemiology*,  genetics,  prevention & control
Chemical
Reg. No./Substance:
0/Hemoglobins, Abnormal; 39346-78-6/hemoglobin D; 9034-61-1/Hemoglobin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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