Document Detail

Strychnine poisoning. Recovery from profound lactic acidosis, hyperthermia, and rhabdomyolysis.
MedLine Citation:
PMID:  6829597     Owner:  NLM     Status:  MEDLINE    
Strychnine poisoning results in a predictable and treatable sequence of events involving blockade of the inhibitory neurotransmitter, extensor muscle spasms, seizures, and respiratory paralysis. These spasms may lead to hyperthermia, profound lactic acidosis, and rhabdomyolysis. Acidosis is primarily attributable to lactate, as indicated by the correlation between arterial pH and log of lactic acid concentration (r = -0.878). Interruption of the strychnine blockade is the primary therapy for strychnine poisoning. Phenobarbital in moderate doses should be the first intervention and anesthetic doses should be used if necessary. Suppression of convulsions will permit successful management of the complications of strychnine poisoning. Our patient survived, even though at one point he had a pH of 6.55, a lactate level of 32 mM/liter, a temperature of 43 degrees C, and rhabdomyolysis with an increased creatine phosphokinase level of 359,000 mU/ml (5,983 mumol/s/liter).
R E Boyd; P T Brennan; J F Deng; D F Rochester; D A Spyker
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  74     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  507-12     Citation Subset:  AIM; IM    
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MeSH Terms
Acidosis / chemically induced*
Body Temperature
Creatine Kinase / blood
Fever / chemically induced*
Glycine / antagonists & inhibitors
Hydrogen-Ion Concentration
Lactates / blood*
Motor Neurons / drug effects
Myoglobinuria / chemically induced*
Phenobarbital / therapeutic use
Seizures / prevention & control
Strychnine / poisoning*
Time Factors
Reg. No./Substance:
0/Lactates; 50-06-6/Phenobarbital; 56-40-6/Glycine; 57-24-9/Strychnine; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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