Document Detail


Struggling behavior during restraint is regulated by stress experience.
MedLine Citation:
PMID:  18466984     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Restraint elicits a number of physiological stress responses that can be increased or decreased in magnitude based on prior stress history. For instance, repeated exposure to restraint leads to habituation of hypothalamic-pituitary-adrenal (HPA) activation to restraint. In contrast, acute restraint after a different repeated stressor leads to facilitation of HPA activity to the novel stress. Acute restraint also elicits a variety of behaviors, including struggling, but the effect of prior stress in regulating behavioral responses to restraint is not clear. The goal of the present studies was to assess struggling during restraint with or without a prior history of repeated stress. Using automated behavioral analysis software (EthoVision), we quantified struggling during restraint. We found that acutely restrained rats exhibited vigorous struggling behavior that declined during a single restraint period. Repeated restraint lead to habituated struggling behavior, whereas acute restraint after repeated swim elicited facilitated struggling behavior. These effects on struggling were found alongside expected differences in HPA activity. Removing stress-induced increases in corticosterone via adrenalectomy did not significantly affect struggling responses to restraint. Overall, restraint-induced struggling appears to be regulated in a manner similar to HPA responses to restraint, but is not dictated by adrenal hormones.
Authors:
Nicola Grissom; Wesley Kerr; Seema Bhatnagar
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Publication Detail:
Type:  Journal Article     Date:  2008-03-29
Journal Detail:
Title:  Behavioural brain research     Volume:  191     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-05-26     Completed Date:  2008-09-24     Revised Date:  2014-04-09    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  219-26     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenalectomy / methods
Adrenocorticotropic Hormone / blood
Analysis of Variance
Animals
Automatic Data Processing / methods
Behavior, Animal
Corticosterone / blood
Freezing Reaction, Cataleptic / physiology*
Habituation, Psychophysiologic*
Male
Rats
Rats, Sprague-Dawley
Restraint, Physical / methods*
Stress, Psychological / etiology*
Swimming
Time Factors
Grant Support
ID/Acronym/Agency:
R01 MH067651/MH/NIMH NIH HHS; R01 MH067651-05/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
9002-60-2/Adrenocorticotropic Hormone; W980KJ009P/Corticosterone
Comments/Corrections

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