| Structures of human nucleosomes containing major histone H3 variants. | |
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MedLine Citation:
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PMID: 21636898 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The nucleosome is the fundamental repeating unit of chromatin, via which genomic DNA is packaged into the nucleus in eukaryotes. In the nucleosome, two copies of each core histone, H2A, H2B, H3 and H4, form a histone octamer which wraps 146 base pairs of DNA around itself. All of the core histones except for histone H4 have nonallelic isoforms called histone variants. In humans, eight histone H3 variants, H3.1, H3.2, H3.3, H3T, H3.5, H3.X, H3.Y and CENP-A, have been reported to date. Previous studies have suggested that histone H3 variants possess distinct functions in the formation of specific chromosome regions and/or in the regulation of transcription and replication. H3.1, H3.2 and H3.3 are the most abundant H3 variants. Here, crystal structures of human nucleosomes containing either H3.2 or H3.3 have been solved. The structures were essentially the same as that of the H3.1 nucleosome. Since the amino-acid residues specific for H3.2 and H3.3 are located on the accessible surface of the H3/H4 tetramer, they may be potential interaction sites for H3.2- and H3.3-specific chaperones. |
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Authors:
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Hiroaki Tachiwana; Akihisa Osakabe; Tatsuya Shiga; Yuta Miya; Hiroshi Kimura; Wataru Kagawa; Hitoshi Kurumizaka |
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Publication Detail:
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Type: Journal Article Date: 2011-05-17 |
Journal Detail:
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Title: Acta crystallographica. Section D, Biological crystallography Volume: 67 ISSN: 1399-0047 ISO Abbreviation: Acta Crystallogr. D Biol. Crystallogr. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305878 Medline TA: Acta Crystallogr D Biol Crystallogr Country: England |
Other Details:
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Languages: eng Pagination: 578-83 Citation Subset: IM |
Affiliation:
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Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho, Shinjyuku-ku, Tokyo 162-8480, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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