Document Detail

Structures of the human ceramide activator protein saposin D.
MedLine Citation:
PMID:  18453694     Owner:  NLM     Status:  MEDLINE    
Saposin D is a sphingolipid activator protein required for the lysosomal breakdown of ceramide to a fatty acid and sphingosine by acid ceramidase. The crystal structure of saposin D has been determined in two different crystal forms, resulting in a total of six crystallographically independent views of this small 80-amino-acid protein. All of the structures are highly similar and reveal the monomeric form of the saposin fold previously seen in the crystal structures of saposins A and C. Saposin D is slightly more compact than the related saposins A and C owing to a slight repositioning of the 'stem' and 'hairpin' regions of the protein.
Konstantin Popovic; Gilbert G Privé
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-04-19
Journal Detail:
Title:  Acta crystallographica. Section D, Biological crystallography     Volume:  64     ISSN:  0907-4449     ISO Abbreviation:  Acta Crystallogr. D Biol. Crystallogr.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-06-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305878     Medline TA:  Acta Crystallogr D Biol Crystallogr     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  589-94     Citation Subset:  IM    
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Crystallography, X-Ray / methods
Models, Molecular
Protein Structure, Secondary*
Saposins / chemistry*
Reg. No./Substance:

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