| Structures from powders: bupropion hydrochloride. | |
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MedLine Citation:
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PMID: 19464134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The crystal structure of bupropion hydrochloride, 1, was fully characterized from powdered crystalline samples, using the ab-initio XRPD technique and a global optimization strategy (simulated annealing), adopting, as starting model, the already known molecular structure of its ethanol solvate, 2. Bupropion hydrochloride crystallizes as a racemate in monoclinic system, space group P2(1)/c with Z=4, a=14.3406(3)A, b=8.7564(2)A, c=11.8801(2)A, beta=78.025(2) degrees , V=1459.34(5)A(3). In the crystals of 1 the molecules interact via strong NH[...]Cl contacts, generating dimeric entities with mu-Cl ions. Further stabilizing contacts, of the CH[...]O are at work, but differently organized in the 1 and 2 phases. The thermal behaviour of the product was assessed by differential scanning calorimetry. |
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Authors:
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Elisabetta Maccaroni; Luciana Malpezzi; Norberto Masciocchi |
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Publication Detail:
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Type: Journal Article Date: 2009-05-03 |
Journal Detail:
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Title: Journal of pharmaceutical and biomedical analysis Volume: 50 ISSN: 1873-264X ISO Abbreviation: J Pharm Biomed Anal Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-06-05 Completed Date: 2009-09-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309336 Medline TA: J Pharm Biomed Anal Country: England |
Other Details:
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Languages: eng Pagination: 257-61 Citation Subset: IM |
Affiliation:
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Dipartimento di Scienze Chimiche e Ambientali, Università dell'Insubria, Via Valleggio 11, I-22100 Como, Italy. emaccaroni@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antidepressive Agents, Second-Generation
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chemistry* Bupropion / chemistry* Calorimetry, Differential Scanning Molecular Structure Powders* X-Ray Diffraction |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents, Second-Generation; 0/Powders; 34841-39-9/Bupropion |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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