Document Detail

Structured regulation of inflammation during respiratory viral infection.
MedLine Citation:
PMID:  20417418     Owner:  NLM     Status:  MEDLINE    
Innate immune cells including macrophages, dendritic cells, and granulocytes are resident within or patrol very different microenvironments in the host. Their activity or responsiveness to antigen is dictated by site-specific factors. Because of the constant exposure to environmental antigens and commensal microorganisms, mucosal immunity needs to be more constrained than peripheral counterparts to prevent unnecessary inflammation. The epithelial surfaces that dominate all mucosal tissues provide an ideal regulator since innate immune cells are often in intimate contact with, or lie immediately beneath, them and a breach in epithelial integrity would signal a damaging event and release innate immunity from their influence. We discuss the role of the respiratory epithelium in raising the threshold of innate immune cell activation at homoeostasis, how its absence triggers innate immunity, and how inflammatory resolution often produces an altered homoeostatic environment that can affect the next inflammatory event at this site.
Tracy Hussell; John Goulding
Related Documents :
19007808 - Differential antimicrobial peptide gene expression patterns during early chicken embryo...
19997068 - Origin and evolution of the adaptive immune system: genetic events and selective pressu...
20566828 - Tlr5 signaling stimulates the innate production of il-17 and il-22 by cd3(neg)cd127+ im...
22093088 - Mammalian lipocalin allergens - insights into their enigmatic allergenicity.
19830728 - Erk/p38 map-kinases and pi3k are involved in the differential regulation of b7-h1 expre...
21297578 - Drosophila ras/mapk signalling regulates innate immune responses in immune and intestin...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Lancet. Infectious diseases     Volume:  10     ISSN:  1474-4457     ISO Abbreviation:  Lancet Infect Dis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2010-05-04     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101130150     Medline TA:  Lancet Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  360-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Immunity, Mucosal*
Respiratory Tract Diseases / immunology*,  pathology*,  virology
Social Control, Formal
Virus Diseases / immunology*,  pathology*
Grant Support
G0400795//Medical Research Council; G0802752//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rhodococcus equi infection.
Next Document:  Long-term Outcome After Laparoscopic Treatment of Heterotopic Pregnancy: 19 Cases.