Document Detail

Structured intermittent therapy with seven-day cycles of HAART for chronic HIV infection: a pilot study in São Paulo, Brazil.
MedLine Citation:
PMID:  16053399     Owner:  NLM     Status:  MEDLINE    
In the last 6 years, an impressive impact of the highly active antiretroviral therapy (HAART) on survival and morbidity in HIV-1-infected individuals has been attained. However, their prolonged use may induce metabolic adverse effects such as lipodistrophy, hypertension, diabetes mellitus, osteopenia and hyperlipidemia. Recently, new strategies such as short-cycle structured intermittent therapy (SIT; 7 days without therapy followed by 7 days with HAART) have been suggested. We tested this strategy in seven (four women and three men; mean of age 39 of years) HIV-positive individuals, all of whom had CD4+ T cell counts greater than 500 cells/mm3 and undetectable plasma viral load for at least 2 years. Our results indicated no opportunistic diseases or CD4 cell count decrease over a mean follow-up of 26 months. No plasma viral replication was detected in five of seven cases. There was a decrease in triglyceride levels to normal range (not statistically significant), but no modification of cholesterol levels. Thus, we recommend a larger clinical trial to determine if SIT is cost effective in developing countries.
Jorge Casseb; Alberto José Da Silva Duarte
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  AIDS patient care and STDs     Volume:  19     ISSN:  1087-2914     ISO Abbreviation:  AIDS Patient Care STDS     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-08-01     Completed Date:  2005-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607225     Medline TA:  AIDS Patient Care STDS     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  X    
Laboratory of Allergy and Clinical and Experimental Immunology, Institute of Infectious Diseases "Emilio Ribas," São Paulo, Brazil.
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MeSH Terms
Antiretroviral Therapy, Highly Active / methods*
CD4-Positive T-Lymphocytes / immunology*
Chronic Disease
Dose-Response Relationship, Drug
Drug Administration Schedule
Follow-Up Studies
HIV Infections / diagnosis*,  drug therapy*
Middle Aged
Pilot Projects
Risk Assessment
Sampling Studies
Severity of Illness Index
Treatment Outcome
Urban Population
Viral Load

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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