Document Detail

Structured tree impedance outflow boundary conditions for 3D lung simulations.
MedLine Citation:
PMID:  20670051     Owner:  NLM     Status:  MEDLINE    
In this paper, we develop structured tree outflow boundary conditions for modeling the airflow in patient specific human lungs. The utilized structured tree is used to represent the nonimageable vessels beyond the 3D domain. The coupling of the two different scales (1D and 3D) employs a Dirichlet-Neumann approach. The simulations are performed under a variety of conditions such as light breathing and constant flow ventilation (which is characterized by very rapid acceleration and deceleration). All results show that the peripheral vessels significantly impact the pressure, however, the flow is relatively unaffected, reinforcing the fact that the majority of the lung impedance is due to the lower generations rather than the peripheral vessels. Furthermore, simulations of a hypothetical diseased lung (restricted flow in the superior left lobe) under mechanical ventilation show that the mean pressure at the outlets of the 3D domain is about 28% higher. This hypothetical model illustrates potential causes of volutrauma in the human lung and furthermore demonstrates how different clinical scenarios can be studied without the need to assume the unknown flow distribution into the downstream region.
Andrew Comerford; Christiane Förster; Wolfgang A Wall
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  132     ISSN:  1528-8951     ISO Abbreviation:  J Biomech Eng     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-30     Completed Date:  2010-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  081002     Citation Subset:  IM    
Institute for Computational Mechanics, Technische Universitat Munchen, D-85747 Garching, Germany.
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MeSH Terms
Airway Resistance / physiology*
Computer Simulation
Lung / physiology*
Models, Biological*
Pulmonary Ventilation / physiology*

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