| Structure and tissue distribution of a trinucleotide-repeat-containing gene (cag-3) expressed specifically in the mouse brain. | |
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MedLine Citation:
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PMID: 16404148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using in silico approaches and RACE we cloned a full length trinucleotide (CAG) repeat-containing cDNA (cag-3). The cDNA is 2478 bp long and the deduced polypeptide consists of 140 amino acids of which 73 are glutamines. The genomic sequence spans approximately 79 kb on mouse chromosome 7 and the gene is composed of four exons. Standard and real-time PCR analyses of several mouse tissues showed that the gene is exclusively expressed in the brain and is not detected in embryonic stages. Within the brain, it is expressed throughout the forebrain region with predominant expression in the hypothalamus and olfactory bulb and very low levels in the mid- and hindbrain. |
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Authors:
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Jin Woo Ji; Hye Lim Yang; Sun Jung Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecules and cells Volume: 20 ISSN: 1016-8478 ISO Abbreviation: Mol. Cells Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-11 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9610936 Medline TA: Mol Cells Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 348-53 Citation Subset: IM |
Affiliation:
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Department of Biology, Dongguk University, Seoul 100-715, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Brain / metabolism* Cloning, Molecular DNA, Complementary / metabolism Gene Expression Mice Mice, Inbred ICR Molecular Sequence Data Polymerase Chain Reaction RNA, Messenger / genetics, metabolism Trinucleotide Repeats / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Complementary; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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