Document Detail


Structure of a stable form of sulfheme.
MedLine Citation:
PMID:  3828290     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A stable green heme was extracted from ferric cyanosulfmyoglobin after it had undergone an internal conversion reaction. After iron removal and conversion to the methyl ester, the resulting green porphyrin was purified by high-pressure liquid chromatography. Visible, 1H NMR, and mass spectrometric studies provided evidence to identify the substituents of the porphyrin. Nuclear Overhauser enhancements enabled an assignment of the single modified pyrrole. Substituent positions 1, 2, 5, 6, 7, and 8 have the original protoporphyrin IX substituents. At ring B, the 4-vinyl group has cyclized with a single sulfur atom to form a fifth ring with a 2,5-dihydrothiophene type of structure.
Authors:
L L Bondoc; M H Chau; M A Price; R Timkovich
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemistry     Volume:  25     ISSN:  0006-2960     ISO Abbreviation:  Biochemistry     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-05-20     Completed Date:  1987-05-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370623     Medline TA:  Biochemistry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8458-66     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Drug Stability
Heme / analogs & derivatives*,  isolation & purification
Horses
Magnetic Resonance Spectroscopy / methods
Muscles
Myoglobin*
Porphyrins
Pyrroles
Spectrophotometry / methods
Grant Support
ID/Acronym/Agency:
GM37870/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Myoglobin; 0/Porphyrins; 0/Pyrroles; 105253-67-6/sulfheme; 14875-96-8/Heme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ATP-induced dissociation of rabbit skeletal actomyosin subfragment 1. Characterization of an isomeri...
Next Document:  Inhibition of malic enzyme by S-oxalylglutathione, a probable in vivo effector.