Document Detail


Structure re-assignment of a metabolite of ampicillin and amoxycillin and epimerization of their penicilloic acids.
MedLine Citation:
PMID:  6132968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Products formed in-vitro from ampicillin and amoxycillin penicilloates have been examined by high-performance liquid chromatography, ultraviolet and nuclear magnetic resonance spectroscopy and thiol group determination and were found to be the 5S epimers of the penicilloic acids. This is in contrast to a published claim that the corresponding penamaldic acids were formed by the treatment used.
Authors:
A E Bird; E A Cutmore; K R Jennings; A C Marshall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  35     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-06-17     Completed Date:  1983-06-17     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  138-43     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amoxicillin / analysis*
Ampicillin / analysis*
Biotransformation
Chromatography, High Pressure Liquid
Isomerism
Magnetic Resonance Spectroscopy
Penicillanic Acid / analysis*
Spectrophotometry, Ultraviolet
Sulfhydryl Compounds / analysis
Chemical
Reg. No./Substance:
0/Sulfhydryl Compounds; 11039-68-2/penicilloic acid; 26787-78-0/Amoxicillin; 69-53-4/Ampicillin; 87-53-6/Penicillanic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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