Document Detail

Structure of rat behavior in hole-board: I) multivariate analysis of response to anxiety.
MedLine Citation:
PMID:  18948127     Owner:  NLM     Status:  MEDLINE    
Aim of present paper was to carry out an analysis of rat behavior in hole-board following different multivariate approaches. Thirty male Wistar rats were observed in a hole-board apparatus and their behavior recorded for 10 min through a digital videocamera for a following frame-by-frame analysis. Both descriptive and multivariate analyses were used. Descriptive analysis showed that roughly 85% of the whole behavioral structure encompassed six patterns appearing during the first minute of observation: walking, climbing, rearing, immobile-sniffing, edge-sniff and head-dip. As to multivariate approach, cluster analysis showed three main dyadic associations: [edge-sniff/head-dip], [walking/climbing], [face-grooming/body-grooming]. Path diagram, obtained on the basis of relative frequencies of transitions among behavioral patterns (stochastic analysis), emphasized cluster analysis results. Adjusted residuals confirmed, from a statistical point of view, the strong relationships among specific patterns. Results demonstrate that immobile-sniffing has a crucial role in rat behavioral organization and head-dip is closely related with edge-sniff which is suggested to be a specific sniffing activity of holes edge never properly considered. Present research shows that multivariate approaches, revealing patterning among different behavioral elements in hole-board, could improve test reliability, providing a more useful tool to investigate behavioral effects of anxiolytic drugs.
Maurizio Casarrubea; Filippina Sorbera; Giuseppe Crescimanno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-09
Journal Detail:
Title:  Physiology & behavior     Volume:  96     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-9     Citation Subset:  IM    
Department of Experimental Medicine, Università di Palermo, Palermo, Italy.
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MeSH Terms
Anxiety / physiopathology*
Behavior, Animal / physiology*
Cluster Analysis
Motor Activity / physiology*
Multivariate Analysis*
Rats, Wistar
Reaction Time / physiology
Stochastic Processes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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