Document Detail


Structure of rat behavior in hole-board: I) multivariate analysis of response to anxiety.
MedLine Citation:
PMID:  18948127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aim of present paper was to carry out an analysis of rat behavior in hole-board following different multivariate approaches. Thirty male Wistar rats were observed in a hole-board apparatus and their behavior recorded for 10 min through a digital videocamera for a following frame-by-frame analysis. Both descriptive and multivariate analyses were used. Descriptive analysis showed that roughly 85% of the whole behavioral structure encompassed six patterns appearing during the first minute of observation: walking, climbing, rearing, immobile-sniffing, edge-sniff and head-dip. As to multivariate approach, cluster analysis showed three main dyadic associations: [edge-sniff/head-dip], [walking/climbing], [face-grooming/body-grooming]. Path diagram, obtained on the basis of relative frequencies of transitions among behavioral patterns (stochastic analysis), emphasized cluster analysis results. Adjusted residuals confirmed, from a statistical point of view, the strong relationships among specific patterns. Results demonstrate that immobile-sniffing has a crucial role in rat behavioral organization and head-dip is closely related with edge-sniff which is suggested to be a specific sniffing activity of holes edge never properly considered. Present research shows that multivariate approaches, revealing patterning among different behavioral elements in hole-board, could improve test reliability, providing a more useful tool to investigate behavioral effects of anxiolytic drugs.
Authors:
Maurizio Casarrubea; Filippina Sorbera; Giuseppe Crescimanno
Related Documents :
22957757 - Cross-talk between toll-like receptor 4 (tlr4) and proteinase-activated receptor 2 (par...
3222177 - Desipramine antagonizes clonidine-induced suppression of dominance in rats: possible in...
11166927 - Effects of lowering barometric pressure on guarding behavior, heart rate and blood pres...
9398467 - Magnetic resonance imaging and behavioral analysis of immature rats with kaolin-induced...
22760927 - Chronic lithium feeding reduces upregulated brain arachidonic acid metabolism in hiv-1 ...
6844737 - Wet-dog body shaking induced by electrical stimulation of hippocampus in the intact and...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-09
Journal Detail:
Title:  Physiology & behavior     Volume:  96     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-04-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  174-9     Citation Subset:  IM    
Affiliation:
Department of Experimental Medicine, Università di Palermo, Palermo, Italy. m.casarrubea@unipa.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / physiopathology*
Behavior, Animal / physiology*
Cluster Analysis
Grooming
Male
Motor Activity / physiology*
Multivariate Analysis*
Rats
Rats, Wistar
Reaction Time / physiology
Stochastic Processes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mech...
Next Document:  The influence of whey protein and glycomacropeptide on satiety in adult humans.