Document Detail


Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.
MedLine Citation:
PMID:  16511068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
Authors:
Rosa Grenha; Vladimir M Levdikov; Mark J Fogg; Elena V Blagova; James A Brannigan; Anthony J Wilkinson; Keith S Wilson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-04-09
Journal Detail:
Title:  Acta crystallographica. Section F, Structural biology and crystallization communications     Volume:  61     ISSN:  1744-3091     ISO Abbreviation:  Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.     Publication Date:  2005 May 
Date Detail:
Created Date:  2006-03-02     Completed Date:  2006-06-19     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  101226117     Medline TA:  Acta Crystallogr Sect F Struct Biol Cryst Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-62     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of York, York YO10 5YW, England.
Data Bank Information
Bank Name/Acc. No.:
PDB/1XE3;  R1XE3SF
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Bacillus anthracis / enzymology*,  metabolism
Cloning, Organism
Crystallography, X-Ray
Models, Molecular
Molecular Sequence Data
Protein Conformation
Protein Structure, Secondary
Purine-Nucleoside Phosphorylase / chemistry*,  metabolism
Sequence Alignment
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
EC 2.4.2.1/Purine-Nucleoside Phosphorylase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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