| Structure and mechanism in salivary proteins from blood-feeding arthropods. | |
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MedLine Citation:
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PMID: 19925819 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The saliva of blood-feeding arthropods contains rich mixtures of ligand binding proteins targeted at inhibiting hemostasis and inflammation in the host. Since blood feeding has evolved many times, different taxonomic groups utilize completely different families of proteins to perform similar tasks. Structural studies performed on a number of these proteins have revealed biologically novel and sophisticated mechanisms used to perform their functions. Here, the results of these structural and mechanistic studies are reviewed. |
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Authors:
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John F Andersen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review Date: 2009-11-26 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: 56 ISSN: 1879-3150 ISO Abbreviation: Toxicon Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-19 Completed Date: 2011-07-13 Revised Date: 2011-12-19 |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: England |
Other Details:
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Languages: eng Pagination: 1120-9 Citation Subset: IM |
Copyright Information:
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Published by Elsevier Ltd. |
Affiliation:
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Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2E-32B Twinbrook 3 Bldg, 12735 Twinbrook Parkway, Rockville, MD 20852, USA. jandersen@niaid.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arthropods / metabolism, physiology* Feeding Behavior Hemeproteins / chemistry, toxicity Insect Bites and Stings Insect Proteins / chemistry*, toxicity Lipocalins / chemistry, toxicity Models, Molecular Protein Structure, Tertiary Saliva / chemistry Salivary Proteins and Peptides / chemistry*, toxicity Structure-Activity Relationship |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AI001012-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemeproteins; 0/Insect Proteins; 0/Lipocalins; 0/Salivary Proteins and Peptides; 0/nitrophorin; 0/triabin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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