Document Detail

Structure and in vitro function of human subcutaneous small arteries in mild heart failure.
MedLine Citation:
PMID:  9612217     Owner:  NLM     Status:  MEDLINE    
The structure and function of subcutaneous small arteries from patients with mild heart failure (n = 27) 6-43 mo after myocardial infarction were compared with vessels from healthy control subjects (n = 10). Patients were randomized to treatment with placebo or the angiotensin-converting enzyme inhibitor ramipril starting 3-10 days after myocardial infarction. Dissected arterial vessels were mounted on a wire myograph for measurement of morphology and isometric tension. Morphology was not different in arteries from the three groups. Responses to norepinephrine, angiotensin II, and electrical field stimulation were similar in arteries from placebo-treated patients with mild heart failure and control subjects. Similarly, endothelium-dependent and -independent relaxation was normal in arteries from patients with mild heart failure. Ramipril therapy was associated with functional alterations: vasoconstrictor responses to norepinephrine and angiotensin II were significantly enhanced compared with placebo (P < 0.001). These data suggest that vascular structure and function are not different in vitro in subcutaneous arteries from placebo-treated patients with mild heart failure. Angiotensin-converting enzyme inhibitor therapy is associated with enhanced vasoconstriction to norepinephrine and angiotensin II, which may reflect upregulation of receptor-mediated events.
N Stephens; M J Drinkhill; A S Hall; S G Ball; A M Heagerty
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Publication Detail:
Type:  Clinical Trial; In Vitro; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of physiology     Volume:  274     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-01     Completed Date:  1998-07-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  C1298-305     Citation Subset:  IM    
Department of Medicine, Manchester Royal Infirmary, United Kingdom.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Arteries / drug effects,  pathology,  physiopathology
Cardiac Output, Low / drug therapy,  pathology*,  physiopathology*
Electric Stimulation
Middle Aged
Ramipril / therapeutic use
Skin / blood supply*
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 87333-19-5/Ramipril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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