| Structure of the human blood platelet membrane glycoprotein Ib alpha gene. | |
| | |
MedLine Citation:
|
PMID: 2845978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The gene for human platelet glycoprotein Ib alpha-chain has been cloned from a genomic cosmid library using a partial cDNA clone as probe. 3530 bp were sequenced including the entire transcribed part, as well as additional 5' and 3' regions. A single intron was found 6 bp upstream of the ATG initiation codon. An exceptionally long exon was identical to the recently published cDNA sequence (1). The 5' upstream promoter region is atypical for eukaryotic genes with only a weak homology to the characteristic promoter consensus sequences. The 3' region contains two repetitive Alu elements, belonging to distinct subfamilies, connected by an oligo(dA) linker. |
| | |
Authors:
|
R H Wenger; N Kieffer; A N Wicki; K J Clemetson |
Related Documents
:
|
7721098 - Conservation of sequences between human and gorilla lineages: adp-ribosyltransferase (n... 18065488 - Analysis of nuclear receptor pseudogenes in vertebrates: how the silent tell their stor... 2833668 - Phylogenetic screening of the human genome: identification of differentially hybridizin... 15526218 - Non-recurrent 17p11.2 deletions are generated by homologous and non-homologous mechanisms. 2901768 - Complete nucleotide sequence and genetic organization of the bacteriocinogenic plasmid,... 17999168 - Population structure of citrus tristeza virus from field argentinean isolates. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: 156 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Oct |
Date Detail:
|
Created Date: 1988-11-21 Completed Date: 1988-11-21 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 389-95 Citation Subset: IM |
Affiliation:
|
Theodor Kocher Institute, University of Berne, Switzerland. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
GENBANK/M22403 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acid Sequence Base Sequence Cloning, Molecular Cosmids DNA / blood, genetics DNA Restriction Enzymes Genes* Humans Molecular Sequence Data Platelet Membrane Glycoproteins / genetics* RNA, Messenger / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Platelet Membrane Glycoproteins; 0/RNA, Messenger; 9007-49-2/DNA; EC 3.1.21.-/DNA Restriction Enzymes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasminogen activator inhibitor 2. Isolation and characterization of the promoter region of the gene...
Next Document: Saposin D: a sphingomyelinase activator.