| Structure-function relationships of protoporphyrin-induced liver injury. | |
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MedLine Citation:
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PMID: 6205639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To further define the pathogenesis of protoporphyric liver disease, perfused rat livers received varying doses of protoporphyrin, and aberrations of hepatic ultrastructure and function were correlated. Results indicated that the relative canalicular volume was equally increased in all protoporphyrin-perfused livers; however, bile flow was only minimally diminished at the smallest protoporphyrin dose employed. Protoporphyrin injured microvilli at the sinusoidal pole and reduced the surface density of the endoplasmic reticulum in a dose-related fashion. No crystalline or amorphous material was detectable, and only slight mitochondrial distortions occurred. Thus, cholestasis did not correlate with canalicular dilatation, the presence of crystalline material, or mitochondrial changes. Liver plasma membrane abnormalities appeared to correlate with functional defects and support a direct hepatotoxicity. Long-term protoporphyrin overload studies are needed to assess differences between hepatic and erythroid (parenteral) sources of protoporphyrin overproduction. |
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Authors:
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R G Lee; D L Avner; M M Berenson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Archives of pathology & laboratory medicine Volume: 108 ISSN: 0003-9985 ISO Abbreviation: Arch. Pathol. Lab. Med. Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-09-20 Completed Date: 1984-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607091 Medline TA: Arch Pathol Lab Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 744-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile / metabolism Bile Canaliculi / drug effects, ultrastructure Cell Membrane / drug effects, ultrastructure Dilatation, Pathologic Dose-Response Relationship, Drug Liver / drug effects*, pathology, ultrastructure Microscopy, Electron Microvilli / drug effects, ultrastructure Perfusion Porphyrins / toxicity* Protoporphyrins / toxicity* Rats Rats, Inbred Strains Staining and Labeling Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Porphyrins; 0/Protoporphyrins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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