Document Detail


Structure, function and regulation of gonadotropin receptors - a perspective.
MedLine Citation:
PMID:  22342845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Luteinizing hormone receptor and follicle stimulating hormone receptor play a crucial role in female and male reproduction. Significant new information has emerged about the structure, mechanism of activation, and regulation of expression of these receptors. Here we provide an overview of the current information on those aspects with an in-depth discussion of the recent developments in the post-transcriptional mechanism of LH receptor expression mediated by a specific LH receptor mRNA binding protein, designated as LRBP. LRBP was identified by electrophoretic gel mobility shift assay using cytosolic fractions from ovaries in the down regulated state. LRBP was purified, its binding site on LH receptor mRNA was identified and characterized. During ligand-induced down regulation, LRBP expression is increased through the cAMP/PKA and ERK signaling pathway, is translocated to translating ribosomes, binds LH receptor mRNA and forms an untranslatable ribonucleoprotein complex. This complex is then routed to the mRNA degradation machinery resulting in diminished levels of both LHR mRNA and cell surface expression of LH receptor. The studies leading to these conclusions are presented.
Authors:
K M J Menon; Bindu Menon
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-02-09
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  356     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  88-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Gene Expression Regulation
Humans
Mutation
Organ Specificity
Phosphotransferases (Alcohol Group Acceptor) / genetics,  metabolism,  physiology
Protein Processing, Post-Translational
Receptors, FSH / genetics,  metabolism,  physiology*
Receptors, LH / genetics,  metabolism,  physiology*
Signal Transduction
Grant Support
ID/Acronym/Agency:
R37 HD006656/HD/NICHD NIH HHS; R37 HD006656-36/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, FSH; 0/Receptors, LH; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.36/mevalonate kinase
Comments/Corrections

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