Document Detail

Structure, function and regulation of gonadotropin receptors - a perspective.
MedLine Citation:
PMID:  22342845     Owner:  NLM     Status:  MEDLINE    
Luteinizing hormone receptor and follicle stimulating hormone receptor play a crucial role in female and male reproduction. Significant new information has emerged about the structure, mechanism of activation, and regulation of expression of these receptors. Here we provide an overview of the current information on those aspects with an in-depth discussion of the recent developments in the post-transcriptional mechanism of LH receptor expression mediated by a specific LH receptor mRNA binding protein, designated as LRBP. LRBP was identified by electrophoretic gel mobility shift assay using cytosolic fractions from ovaries in the down regulated state. LRBP was purified, its binding site on LH receptor mRNA was identified and characterized. During ligand-induced down regulation, LRBP expression is increased through the cAMP/PKA and ERK signaling pathway, is translocated to translating ribosomes, binds LH receptor mRNA and forms an untranslatable ribonucleoprotein complex. This complex is then routed to the mRNA degradation machinery resulting in diminished levels of both LHR mRNA and cell surface expression of LH receptor. The studies leading to these conclusions are presented.
K M J Menon; Bindu Menon
Related Documents :
21139245 - Stilbene derivatives as human 5-ht(6) receptor antagonists from the root of caragana si...
16188935 - Receptor-activity-modifying proteins are required for forward trafficking of the calciu...
22739235 - Neuregulin-1 exerts protective effects against neurotoxicities induced by c-terminal fr...
22659115 - Vasoconstrictor 5-ht receptors in the smooth muscle of the rat middle cerebral artery.
7085635 - Energetics of gamma-aminobutyrate transport in rat brain synaptosomes.
15044185 - Expression of npy y1 and y5 receptors in the hypothalamic paraventricular nucleus of ag...
Publication Detail:
Type:  Journal Article; Review     Date:  2012-02-09
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  356     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-04-16     Completed Date:  2012-08-02     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  88-97     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Gene Expression Regulation
Organ Specificity
Phosphotransferases (Alcohol Group Acceptor) / genetics,  metabolism,  physiology
Protein Processing, Post-Translational
Receptors, FSH / genetics,  metabolism,  physiology*
Receptors, LH / genetics,  metabolism,  physiology*
Signal Transduction
Grant Support
Reg. No./Substance:
0/Receptors, FSH; 0/Receptors, LH; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis.
Next Document:  IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -depend...