Document Detail


Structure and function of receptors coupled to G proteins.
MedLine Citation:
PMID:  8024808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Direct structural data on receptors coupled to G proteins were obtained last year in the form of a low resolution projection map of rhodopsin. A large number of receptor sequences have now been determined and detailed analysis of these has provided structural information about the receptors. New results from site-directed mutagenesis experiments can be examined in conjunction with the structural information from sequence analysis and the rhodopsin map. The identification of constitutively active mutated receptors has influenced our understanding of normal receptor equilibria.
Authors:
J M Baldwin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  6     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-11     Completed Date:  1994-08-11     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  180-90     Citation Subset:  IM    
Affiliation:
MRC Laboratory of Molecular Biology, Cambridge, UK.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Binding Sites
Cell Membrane / metabolism
GTP-Binding Proteins / chemistry*,  metabolism*
Humans
Ligands
Mutagenesis, Site-Directed
Protein Structure, Secondary*
Receptors, Cell Surface / chemistry*,  metabolism*
Rhodopsin / chemistry*,  metabolism
Chemical
Reg. No./Substance:
0/Ligands; 0/Receptors, Cell Surface; 9009-81-8/Rhodopsin; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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