| Structure and function of human amphiregulin: a member of the epidermal growth factor family. | |
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MedLine Citation:
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PMID: 2466334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined. The truncated form contains 78 amino acids, whereas a larger form of amphiregulin contains six additional amino acids at the amino-terminal end. The amino-terminal half of amphiregulin is extremely hydrophilic and contains unusually high numbers of lysine, arginine, and asparagine residues. The carboxyl-terminal half of amphiregulin (residues 46 to 84) exhibits striking homology to the epidermal growth factor (EGF) family of proteins. Amphiregulin binds to the EGF receptor but not as well as EGF does. Amphiregulin fully supplants the requirement for EGF or transforming growth factor-alpha in murine keratinocyte growth, but it is a much weaker growth stimulator in other cell systems. |
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Authors:
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M Shoyab; G D Plowman; V L McDonald; J G Bradley; G J Todaro |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 243 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1989 Feb |
Date Detail:
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Created Date: 1989-04-07 Completed Date: 1989-04-07 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1074-6 Citation Subset: IM |
Affiliation:
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Oncogen, Seattle, WA 98121. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Binding, Competitive Cell Division Epidermal Growth Factor / physiology Epidermis / cytology Glycoproteins / physiology* Growth Substances / physiology* Humans Intercellular Signaling Peptides and Proteins* Keratins / metabolism Mice Molecular Sequence Data Radioligand Assay Receptor, Epidermal Growth Factor / metabolism Sequence Homology, Nucleic Acid Transforming Growth Factors / physiology |
| Chemical | |
Reg. No./Substance:
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0/Glycoproteins; 0/Growth Substances; 0/Intercellular Signaling Peptides and Proteins; 117147-70-3/amphiregulin; 62229-50-9/Epidermal Growth Factor; 68238-35-7/Keratins; 76057-06-2/Transforming Growth Factors; EC 2.7.10.1/Receptor, Epidermal Growth Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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