| Structure and function of ghrelin. | |
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MedLine Citation:
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PMID: 18193177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The endogenous ligand for growth-hormone secretagogue receptor (GHS-R) was purified from the stomach and we named it "ghrelin", after a word root ("ghre") in Proto-Indo-European languages meaning "grow", since ghrelin has potent growth hormone (GH) releasing activity. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Ghrelin is orexigenic; it is secreted from the stomach and circulates in the blood stream under fasting conditions, indicating that it transmits a hunger signal from the periphery to the central nervous system. Taking into account all these activities, ghrelin plays important roles for maintaining growth hormone release and energy homeostasis in vertebrates. The diverse functions of ghrelin raise the possibility of its clinical application for GH deficiency, eating disorder, gastrointestinal disease, cardiovascular disease, osteoporosis and aging, etc. |
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Authors:
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Masayasu Kojima; Kenji Kangawa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Results and problems in cell differentiation Volume: 46 ISSN: 0080-1844 ISO Abbreviation: Results Probl Cell Differ Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-15 Completed Date: 2008-08-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0173555 Medline TA: Results Probl Cell Differ Country: Germany |
Other Details:
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Languages: eng Pagination: 89-115 Citation Subset: IM |
Affiliation:
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Molecular Genetics, Institute of Life Science, Kurume University, Hyakunenkouen 1-1, Kurume, Fukuoka, Japan. mkojima@lsi.kurume-u.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Arcuate Nucleus / metabolism Brain / metabolism Ghrelin / chemistry, physiology* Homeostasis Humans Hypothalamus / metabolism Ligands Models, Biological Molecular Sequence Data Motilin / metabolism Nervous System Sequence Homology, Amino Acid |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Ligands; 0/ghrelin, des-n-octanoyl; 52906-92-0/Motilin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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