Document Detail


Structure and function of ghrelin.
MedLine Citation:
PMID:  18193177     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The endogenous ligand for growth-hormone secretagogue receptor (GHS-R) was purified from the stomach and we named it "ghrelin", after a word root ("ghre") in Proto-Indo-European languages meaning "grow", since ghrelin has potent growth hormone (GH) releasing activity. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Ghrelin is orexigenic; it is secreted from the stomach and circulates in the blood stream under fasting conditions, indicating that it transmits a hunger signal from the periphery to the central nervous system. Taking into account all these activities, ghrelin plays important roles for maintaining growth hormone release and energy homeostasis in vertebrates. The diverse functions of ghrelin raise the possibility of its clinical application for GH deficiency, eating disorder, gastrointestinal disease, cardiovascular disease, osteoporosis and aging, etc.
Authors:
Masayasu Kojima; Kenji Kangawa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Results and problems in cell differentiation     Volume:  46     ISSN:  0080-1844     ISO Abbreviation:  Results Probl Cell Differ     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-15     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0173555     Medline TA:  Results Probl Cell Differ     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-115     Citation Subset:  IM    
Affiliation:
Molecular Genetics, Institute of Life Science, Kurume University, Hyakunenkouen 1-1, Kurume, Fukuoka, Japan. mkojima@lsi.kurume-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Arcuate Nucleus / metabolism
Brain / metabolism
Ghrelin / chemistry,  physiology*
Homeostasis
Humans
Hypothalamus / metabolism
Ligands
Models, Biological
Molecular Sequence Data
Motilin / metabolism
Nervous System
Sequence Homology, Amino Acid
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Ligands; 0/ghrelin, des-n-octanoyl; 52906-92-0/Motilin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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