| Structure-function correlations in erythropoietin formation and oxygen sensing in the kidney. | |
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MedLine Citation:
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PMID: 1753679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and mechanism of oxygen sensing in the kidney. In addition to causing an increase in the number of cells containing EPO messenger RNA, anemia provokes structural changes exclusively in the cortical labyrinth. Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery. |
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Authors:
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M Le Hir; K U Eckardt; B Kaissling; S T Koury; A Kurtz |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Klinische Wochenschrift Volume: 69 ISSN: 0023-2173 ISO Abbreviation: Klin. Wochenschr. Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-01-27 Completed Date: 1992-01-27 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 2985205R Medline TA: Klin Wochenschr Country: GERMANY |
Other Details:
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Languages: eng Pagination: 567-75 Citation Subset: IM |
Affiliation:
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Medizinische Universitätspoliklinik, Kantonsspital Basel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia
/
blood*,
pathology Animals Anoxia / blood*, pathology Endothelium, Vascular / pathology, physiopathology Erythropoietin / biosynthesis* Humans Kidney / pathology, physiopathology* Kidney Tubules, Proximal / pathology, physiopathology Oxygen / blood* |
| Chemical | |
Reg. No./Substance:
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11096-26-7/Erythropoietin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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